Results 41 to 50 of about 6,085 (188)
Respirology Case Reports, 2020 A 63‐year‐old man suspected of having lung cancer underwent right upper lobectomy and was diagnosed with large cell neuroendocrine carcinoma (LCNEC). Eleven months after surgery, he developed an oligorecurrence in the adrenal gland and underwent left ...
Hiroki Sato +5 more
doaj +1 more source
World Journal of Surgical Oncology, 2018 Background The response to temozolomide (TMZ) treatment in small-cell lung cancer (SCLC) correlated with O(6)-methylguanine -DNA methyltransferase (MGMT) promoter methylation. 1p/19q co-deletion within oligodendroglioma is a responsive predictor for TMZ.
Lei Lei +4 more
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New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma
Molecular & Cellular Oncology, 2020 High-grade neuroendocrine lung carcinomas (LCNEC, SCLC) are recalcitrant cancers for which no optimal management has been achieved. We have recently described two models of LCNEC and SCLC developed upon inactivation of 4 tumor suppressors genes (Rb1 (RB ...
Mirentxu Santos
doaj +1 more source
Pure Large Cell Neuroendocrine Carcinoma of the Ovary with Metastasis to Cervix: A Rare Case Report and Review of Literature [PDF]
Journal of Clinical and Diagnostic Research, 2016 Ovarian Large Cell Neuroendocrine Carcinoma (LCNEC) is a recently described rare entity, which even more rarely occurs in a ‘pure’ form without any associated surface epithelial-stromal or germ cell component.
Lakshmi Agarwal +2 more
doaj +1 more source
Scientific Reports, 2022 The optimal systemic treatment of advanced large cell neuroendocrine carcinoma (LCNEC) is still controversial. We intend to explore advanced LCNEC through SEER database, construct nomogram model of advanced LCNEC, and understand the effect of different ...
Lu Xia +3 more
doaj +1 more source
Case Report: Large Cell Neuroendocrine Carcinoma of the Palatine Tonsil in a 76‐Year‐Old Patient
Head &Neck, EarlyView.ABSTRACT Background Large cell neuroendocrine carcinoma (LCNEC) of the palatine tonsil is an extremely rare malignancy characterized by an aggressive clinical course and poor prognosis. Its nonspecific presentation often delays diagnosis. Methods We present the case of a 76‐year‐old female patient admitted to the Emergency Department with throat ...
Agnieszka Bugaj +5 more
wiley +1 more source
Large cell neuroendocrine carcinoma with a solitary brain metastasis and low Ki-67: a unique subtype
Endocrine Connections, 2019 Introduction: Stage IV large cell neuroendocrine carcinoma (LCNEC) of the lung generally presents as disseminated and aggressive disease with a Ki-67 proliferation index (PI) 40–80%.
B C M Hermans +8 more
doaj +1 more source
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder [PDF]
Journal of Pathology and Translational Medicine, 2018 Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-
Jiyoon Jung +7 more
doaj +1 more source
TROP2 immunoreactivity in pulmonary large cell neuroendocrine carcinoma
Histopathology, EarlyView.Frequently positive TROP2 IHC suggests that TROP2 antibody‐drug conjugates may be potential treatments for LCNEC. Introduction TROP2 antibody‐drug conjugates have shown promising anti‐tumour activity, but neither the activity of these agents nor TROP2 expression has been well studied in pulmonary large cell neuroendocrine carcinoma (LCNEC), a rare and ...
Michael Minkley +6 more
wiley +1 more source