Results 61 to 70 of about 6,085 (188)

Image_2_Molecular Characterization and Prognostication of Large Cell Neuroendocrine Carcinoma and Large Cell Carcinoma.tif

, 2022
PurposeLarge cell neuroendocrine carcinoma (LCNEC) and classic large cell carcinoma (LCC) are two distinct entities with different histological and biological characteristics. However, the mutational profiles and the clinical behavior of the two subtypes
Liming Sheng (11945858), Ying Chen (9697), Minyan Xing (9967157), Xianghui Du (8601651), Lei Cheng (171055), Xiaoying Cui (134632), Guojie Xia (9967154), Di Wang (329735)   +7 more
core   +1 more source

Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy [PDF]

, 2015
Lung neuroendocrine tumors are a heterogeneous subtype of pulmonary cancers representing approximately 20% of all lung cancers, including small-cell lung cancer (SCLC) and large-cell neuroendocrine carcinoma (LCNEC).
Ciardiello, Fortunato, Della Corte, Carminia Maria, Morgillo, Floriana, Fasano, Morena, Papaccio, Federica   +4 more
core   +2 more sources

Cervical Small Cell Neuroendocrine Carcinoma Initially Detected on Cytology: Diagnostic Pitfalls and Clues

Cytopathology, Volume 37, Issue 5, Page 555-559, September 2026.
This case describes the initial detection of cervical small cell neuroendocrine carcinoma on conventional endometrial and cervicovaginal liquid‐based cytology. Given its rarity and high aggressiveness, early recognition and rapid, intensive treatment are crucial for improving patient outcomes.
Yesul Jeong
wiley   +1 more source

The Unmet Diagnostic and Treatment Needs in Large Cell Neuroendocrine Carcinoma of the Lung

Current Oncology, 2023
Large cell neuroendocrine carcinoma of the lung (LCNEC) is currently classified as a rare lung cancer subtype, but given the high incidence of lung cancer, the overall number of cases is considerable.
Catalin Buium, Serban Negru, Diana N. Ionescu, Mircea Dediu   +3 more
doaj   +1 more source

Demographic, clinical and pathologic characteristics of patients with large cell neuroendocrine carcinoma (LCNEC) of the lung from the SEER 18 database, 2004–2015 (n = 3048).

, 2019
Demographic, clinical and pathologic characteristics of patients with large cell neuroendocrine carcinoma (LCNEC) of the lung from the SEER 18 database, 2004–2015 (n = 3048).
Yanqi He (3714628), Yu Chen (29959), Han Liu (288039), Shuai Wang (109515)   +3 more
core   +1 more source

Redefining the Role of Chemotherapy and Targeted Cytotoxic Delivery in Lung Neuroendocrine Tumors

Thoracic Cancer, Volume 17, Issue 16, August 2026.
Perioperative chemotherapy utility remains uncertain and lacks universal standardization. Platinum/etoposide shows suboptimal efficacy in lung NET (neuroendocrine tumors); oral alkylators (temozolomide) alone or in combination (e.g., with capecitabine), and cabozantinib offer promising disease control.
Alice Laffi, Giuseppe Lamberti, Anna La Salvia   +2 more
wiley   +1 more source

当院で経験した肺大細胞神経内分泌癌(LCNEC)の臨床病理学的検討 [PDF]

肺大細胞神経内分泌癌(以下LCNEC)は、WHO分類で肺癌の大細胞癌に分類されるが、小細胞癌と類似した生物学的特徴を有するとされている。当院では2002年1月から2006年6月までに、4例のLCNECを診断した。それぞれの臨床経過、治療、病理学的特徴について検討した。治療は化学療法と放射線療法が3例、肺葉切除術と術後化学療法が1例であった。LCNECは一般に予後不良とされているが、われわれの症例でも、2006年11月現在、診断時からそれぞれ10ヶ月、12ヶ月、7ヶ月、9ヶ月で死亡している ...
高崎, 寛司, 櫻井, 裕幸, 柿崎, 有美子, 小山, 敏雄, 山下, 高明, 宮下, 義啓, 羽田, 真朗   +6 more
core   +1 more source

Table_2_Molecular Characterization and Prognostication of Large Cell Neuroendocrine Carcinoma and Large Cell Carcinoma.xlsx

, 2022
PurposeLarge cell neuroendocrine carcinoma (LCNEC) and classic large cell carcinoma (LCC) are two distinct entities with different histological and biological characteristics. However, the mutational profiles and the clinical behavior of the two subtypes
Liming Sheng (11945858), Ying Chen (9697), Minyan Xing (9967157), Xianghui Du (8601651), Lei Cheng (171055), Xiaoying Cui (134632), Guojie Xia (9967154), Di Wang (329735)   +7 more
core   +1 more source

Differential response in patients with large cell neuroendocrine carcinoma of the lung to initial therapy: A case series

Cancer Reports, 2023
Background Large cell neuroendocrine tumors of the lung (LCNEC) are rare. Chemotherapy with the small cell lung carcinoma (SCLC) regimen is the most appropriate treatment for LCNEC.
Yutaka Takahara, Takuya Tanaka, Yoko Ishige, Ikuyo Shionoya, Kouichi Yamamura, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Shiro Mizuno   +12 more
doaj   +1 more source

Impact of Thyroid Transcription Factor‐1 Expression on Outcomes of Platinum‐Based Chemoimmunotherapy in Advanced or Recurrent Non‐Squamous Non‐Small Cell Lung Cancer

Thoracic Cancer, Volume 17, Issue 13, July 2026.
Among thyroid transcription factor‐1 (TTF‐1) negative non‐squamous (non‐sq) NSCLC patients, platinum and pemetrexed plus pembrolizumab showed comparable and preferable efficacy in terms of progression‐free survival and overall survival to that observed in TTF‐1‐positive patients.
Ryohei Kamada, Hiroshi Yokouchi, Shohei Mizobuchi, Ken Kuwahara, Yasushi Mizukami, Hidenori Mizugaki, Noriyuki Yamada, Hajime Asahina, Hirofumi Adachi, Yoshihiro Matsuno, Satoshi Oizumi   +10 more
wiley   +1 more source