Results 51 to 60 of about 6,085 (188)

Clinical features of large cell neuroendocrine carcinoma: a population-based overview [PDF]

, 2016
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an orphan disease and few data are available on its clinical characteristics. Therefore, we analysed LCNEC registered in the Netherlands Cancer Registry, and compared data with small cell lung ...
Houben, Ruud, Damhuis, Ronald A., Derks, Jules L., van Suylen, Robert Jan, Speel, Ernst-Jan M., Thunnissen, Erik, Dingemans, Anne-Marie C., van Suylen, Robert-Jan, Hendriks, Lizza. E., Groen, Harry J. M., Buikhuisen, Wieneke A., Hendriks, Lizza E., Speel, Ernst J. M.   +12 more
core   +2 more sources

Distinct Rb expression pattern in HPV‐associated neuroendocrine carcinomas of the uterine cervix

Histopathology, EarlyView.
Most uterine cervical neuroendocrine carcinoma (UCNEC) cases are HPV‐associated and are characterized by partial loss of Rb, p16 overexpression, and cyclin D1 negativity. A minority of UCNECs exhibit a distinct pattern, characterized by HPV negativity, retained Rb expression, focal p16 expression and cyclin D1 positivity.
Nobuko Yasutake, Misato Komamizu, Takeshi Iwasaki, Ryosuke Kuga, Tomomi Manako, Mikiko Hashisako, Rina Jiromaru, Tomoko Sho, Norihito Yuge, Kenzo Sonoda, Hideaki Yahata, Yoshinao Oda, Hidetaka Yamamoto   +12 more
wiley   +1 more source

Primary large cell neuroendocrine carcinoma of the distal ureter: A rare entity

Human Pathology: Case Reports, 2021
Large cell neuroendocrine carcinoma (LCNEC) of the ureter is an extremely rare entity. Herein, we present a case of primary LCNEC of the distal ureter in an 80-year-old male with a history of intermittent hematuria and a mass in the right distal ureter ...
Harpreet Kaur Rai, George Goucher, Jehonathan H. Pinthus, Phillip Williams   +3 more
doaj   +1 more source

Mixed Neuroendocrine—Non‐Neuroendocrine Neoplasm (MiNEN) of the Gallbladder. A Case Report From a Low‐Resource Setting

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Mixed neuroendocrine–non‐neuroendocrine neoplasms (MiNENs) of the gallbladder are exceedingly rare entities. We report a case of a 35‐year‐old female with a palpable right hypochondrial mass. Imaging demonstrated a large polypoid gallbladder lesion with periportal lymphadenopathy. The patient underwent open cholecystectomy with lymphadenectomy.
Muhammad Farhan, Muhammad Imran, Beenish Sabir, Khalil Ahmad, Farheen Khan, Shahid Hussain, Zohaib Ahmed, Muhammad Asim, Iqra Mehmood, Rahmat Gul Omarzai   +9 more
wiley   +1 more source

Large-cell neuroendocrine carcinoma of the gynecologic tract: Prevalence, survival outcomes, and associated factors

Frontiers in Oncology, 2022
BackgroundWe aimed to assess the clinical behavior of gynecologic large-cell neuroendocrine carcinoma (LCNEC) via a retrospective analysis of data from 469 patients.MethodsPatients diagnosed with gynecologic LCNEC from 1988 to 2015 were identified using ...
Li Pang, Jie Chen, Xiaohan Chang
doaj   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, Volume 117, Issue 10, Page 2619-2635, October 2026.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Large Cell Neuroendocrine Carcinoma of the Lung: Current Understanding and Challenges

, 2022
Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare and highly aggressive type of lung cancer, with a complex biology that shares similarities with both small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC).
Andrea Ardizzoni, Dario De Biase, Davide Campana, Giambattista Siepe, Paola Valeria Marchese, Cristina Mosconi, Francesco Panzuto, Elisa Andrini, Giuseppe Lamberti   +8 more
core   +1 more source

Immunological Features of Neuroendocrine Neoplasms and Adrenal Tumors

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Neuroendocrine neoplasms, which occur throughout the human body, as well as adrenocortical carcinoma and pheochromocytoma, which originate in the adrenal gland, are primarily classified as rare malignancies. Immunotherapy, including immune checkpoint inhibitors (ICIs), is generally not incorporated into the standard care protocols for these ...
Akihiro Ohmoto, Shunji Takahashi, Shigehisa Kitano   +2 more
wiley   +1 more source

Primary Lung Carcinoma with a Component of Large Cell Neuroendocrine Carcinoma (LCNEC)

Haigan, 2008
目的．大細胞神経内分泌癌は臨床病理学的に新たに確立されたまれな腫瘍であるが，その組織像は均一でないことがある．この研究の目的は，当院で経験した大細胞神経内分泌癌の成分を含んだ混合型大細胞神経内分泌癌もしくは混合型小細胞癌の臨床病理学的特徴を解明することである．対象．2003年4月から2008年3月までの間に，大細胞神経内分泌癌の成分を含んだ混合型大細胞神経内分泌癌もしくは混合型小細胞癌と診断された4例を対象とした．結果．性別は全例男性であり，年齢は65～85歳で平均76.8歳であった．術前のpositron emission tomography（PET）with 18F-fluorodeoxyglucose（FDG）検査では全例腫瘍に高度な集積が認められた．術式は区域切除が1例，肺葉切除が3例で ...
Maeda, Ryo, Isowa, Noritaka, Kawasaki, Yuji, Tokuyasu, Hirokazu, Touge, Hirokazu   +4 more
openaire   +2 more sources

Pattools‑implemented methylation vector analysis reveals aberrant subtype‑specific methylation in lung cancer across tissue and plasma cfDNA

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. 115 tissue samples across five lung cancer subtypes and matched plasma cfDNA were profiled by WGBS. 2. Pattools implements methylation vector (MV) clustering to isolate tumour‐specific fragments from immune and cell‐origin signals in bulk BS‐seq. 3.
Zehua Dong, Yifeng Luo, Tingting Hu, Yihang Cheng, Qiaoling Ren, Li Xu, Yuan Tan, Wei Li, Yaoxiang Sun, Mingzhi Chen, Zhonghua Shen, Bin Zhang, Youhuang Bai, Yue Tao, Zhihong Cao, Deqiang Sun   +15 more
wiley   +1 more source