Results 71 to 80 of about 6,085 (188)

Nasopharyngeal Large Cell Neuroendocrine Carcinoma Synchronized With Nasopharyngeal Squamous Cell Carcinoma: A Case Report and Review of Literature

Ear, Nose & Throat Journal
Neuroendocrine carcinomas (NECs) are poorly differentiated neuroendocrine tumors of the upper respiratory tract. We present an extremely rare case of nasopharyngeal large cell neuroendocrine carcinoma (LCNEC) synchronized with nasopharyngeal squamous ...
Yu-Wen Lin MD, Ching-Heng Ting MD, MS, Tung-Ying Chen MD, Yi-Shing Leu MD   +3 more
doaj   +1 more source

Plasma Protein Analysis for Biomarker Discovery in Lung Cancer Treated With Atezolizumab Combination Therapy in J‐TAIL‐2

Cancer Science, Volume 117, Issue 7, Page 1948-1960, July 2026.
BLURB FOR ETOC: The J‐TAIL‐2 study (NCT04501497) evaluated the efficacy and safety of atezolizumab, an anti‐programmed death‐ligand 1, plus chemotherapy in patients with non‐small cell lung cancer (NSCLC) and extensive‐stage small cell lung cancer (ES‐SCLC) in real‐world settings.
Yasushi Goto, Makoto Nishio, Kadoaki Ohashi, Atsushi Osoegawa, Eiki Kikuchi, Hideharu Kimura, Junichi Shimizu, Eisaku Miyauchi, Hiroshige Yoshioka, Ichiro Yoshino, Toshihiro Misumi, Yasutaka Watanabe, Nobuyuki Katakami, Akira Kisohara, Masafumi Yamaguchi, Hirotaka Kuroki, Masamichi Sugimoto, Hisao Ashimura, Misa Tanaka, Akihiko Gemma   +19 more
wiley   +1 more source

Genomic alterations (GA) and tumor mutational burden (TMB) in large cell neuroendocrine carcinoma of lung (L-LCNEC) as compared to small cell lung carcinoma (SCLC) as assessed via comprehensive genomic profiling (CGP).

, 2017
8517 Background: SCLC and L-LCNEC are aggressive neoplasms that are both associated with smoking history and are thought to overlap in clinical, histogenetic, and genomic features.
Trever Grant Bivona, Shridar Ganesan, Keerthi Tamragouri, Jon Chung, Alexa Betzig Schrock, Jeffrey S. Ross, Sai-Hong Ignatius Ou, Siraj Mahamed Ali, Francis J. Giles, Phil Stephens, Young Kwang Chae, Victoria Wang, James Suh, Manish Patel, Bhaskar Kolla, Vamsidhar Velcheti, Vincent A. Miller   +16 more
core   +1 more source

Table_1_Comparative Study of Pulmonary Combined Large-Cell Neuroendocrine Carcinoma and Combined Small-Cell Carcinoma in Surgically Resected High-Grade Neuroendocrine Tumors of the Lung.docx

, 2021
ObjectivesPulmonary large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC) are both classified as pure and combined subtypes. Due to the low incidence and difficult diagnosis of combined LCNEC (C-LCNEC) and combined SCLC (C-SCLC ...
Baohui Han (102759), Jun Lu (36049), Wei Zhang (405), Lei Cheng (171055), Ya Chen (1437550), Minjuan Hu (6468194), Yanwei Zhang (690019), Yanan Wang (123548), Zhengyu Yang (2429872), Fangfei Qian (11464960)   +9 more
core   +1 more source

High prevalence of loss of Claudin‐18 expression in invasive non‐mucinous lung adenocarcinoma: Potential diagnostic implications in routine practice

Histopathology, Volume 89, Issue 1, Page 81-97, July 2026.
Loss of Claudin‐18 (Cldn18) expression is a frequent and specific feature of non‐mucinous lung adenocarcinoma (NM‐LUAD). Cldn18 immunohistochemistry may serve as an ancillary tool for distinguishing malignant from non‐neoplastic alveolar epithelium, as well as for differentiating NM‐LUADs with mucin production from M‐LUADs, particularly in small or ...
Stefano Lucà, Marco Montella, Mario Fordellone, Riccardo Monti, Maria Giulia Disanto, Giuseppa Zannini, Marina Accardo, Maria Ali, Gaetano Di Guida, Carminia Maria Della Corte, Beatrice Leonardi, Severo Campione, Valerio Nardone, Floriana Morgillo, Alfonso Fiorelli, Luisella Righi, Mattia Barbareschi, Luka Brcic, Renato Franco   +18 more
wiley   +1 more source

Patients With Stage III PLCNEC Advocated for Radiotherapy Combined With Chemotherapy While With Stage IV Focus on Individualized Management: Evidence From SEER

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background PLCNEC is a rare and highly aggressive lung cancer with a poor prognosis. Multimodal therapy, primarily chemotherapy‐based, is the standard for advanced PLCNEC, but the role of radiotherapy remains unclear. Methods We analyzed 1086 PLCNEC patients receiving chemotherapy from the Surveillance, Epidemiology, and End Results (SEER ...
Yuze Zhao, Guantong Liu, Haitao Li, Yu Li, Ting Lin, Zefeng Xie   +5 more
wiley   +1 more source

Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot, Benjamin Chevalier, Thomas Walter, Benjamin Gibert, Maria Ouzounova   +4 more
wiley   +1 more source

The pulmonary large cell neuroendocrine carcinomas - a comperative study on demographic and clinical characteristics, therapy and prognosis

, 2018
Das großzellig-neuroendokrine Lungenkarzinom (LCNEC) ist ein seltener Tumor und stellt eine besonders aggressive Tumorentität dar. In der aktuellen Klassifikation der Weltgesundheitsorganisation (WHO) von 2015 wird es als Subtyp der pulmonalen ...
Warkus, Stephanie
core   +1 more source

Table_1_Molecular Characterization and Prognostication of Large Cell Neuroendocrine Carcinoma and Large Cell Carcinoma.docx

, 2022
PurposeLarge cell neuroendocrine carcinoma (LCNEC) and classic large cell carcinoma (LCC) are two distinct entities with different histological and biological characteristics. However, the mutational profiles and the clinical behavior of the two subtypes
Liming Sheng (11945858), Ying Chen (9697), Minyan Xing (9967157), Xianghui Du (8601651), Lei Cheng (171055), Xiaoying Cui (134632), Guojie Xia (9967154), Di Wang (329735)   +7 more
core   +1 more source

Pellagra From Tryptophan Depletion in Carcinoid Syndrome due to a Pulmonary Atypical Carcinoid Neuroendocrine Tumor

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Pellagra may complicate functioning pulmonary atypical carcinoid and present as a subtle acral dermatosis rather than the classical photo‐distributed rash. In neuroendocrine tumor patients with chronic diarrhea and new skin changes, clinicians should suspect niacin deficiency and consider empiric nicotinamide, even when niacin assays are ...
Ahmar Iftikhar Talib, Cora Marks, Sheikh Saleem   +2 more
wiley   +1 more source