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Management of Large Cell Neuroendocrine Carcinoma [PDF]

Frontiers in Oncology, 2021
BackgroundLarge cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive cancer with a dismal prognosis. The majority of cases occur in the lung and the gastrointestinal tract; however, it can occur throughout the body.
Virginia Corbett, Susanne Arnold, Lowell Anthony, Aman Chauhan   +3 more
doaj   +2 more sources

Gynecologic large cell neuroendocrine carcinoma: A review [PDF]

Rare Tumors, 2020
Large cell neuroendocrine carcinomas (LCNEC) are rare, aggressive high-grade neuroendocrine neoplasms within the neuroendocrine cell lineage spectrum. This manuscript provides a detailed review of published literature on LCNEC of gynecological origin. We
Grant Burkeen, Aman Chauhan, Rohitashva Agrawal, Riva Raiker, Jill Kolesar, Lowell Anthony, B. Mark Evers, Susanne Arnold   +7 more
doaj   +2 more sources

Clinicopathologic Disease Characteristics and Their Association with Adjuvant Chemotherapy Outcomes in Pulmonary Large-Cell Carcinoma Patients with or Without Neuroendocrine Features

Diagnostics
Background: Large-cell carcinoma (LCC) and large-cell neuroendocrine carcinoma (LCNEC) are kinds of rare lung tumors classified as distinct forms of non-small-cell lung cancer (NSCLC).
Doğan Bayram, Oznur Bal, Efe Cem Erdat, Serhat Sekmek, Saliha Yılmaz, Perihan Perkin, Süleyman Gökalp Güneş, Efnan Algin, Bülent Mustafa Yenigün   +8 more
doaj   +2 more sources

Efficacy of second-line chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma

Scientific Reports
The efficacy of second-line chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma (LCNEC) is unclear. This study aimed to evaluate the efficacy of second-line chemotherapy in patients with pulmonary LCNEC.
Yuko Iida, Kazushige Wakuda, Hirotsugu Kenmotsu, Kosei Doshita, Hiroaki Kodama, Naoya Nishioka, Eriko Miyawaki, Taichi Miyawaki, Nobuaki Mamesaya, Haruki Kobayashi, Shota Omori, Ryo Ko, Akira Ono, Tateaki Naito, Haruyasu Murakami, Takashi Sugino, Yasuhiro Gon, Toshiaki Takahashi   +17 more
doaj   +2 more sources

First-line selpercatinib for a patient with RET fusion-positive pulmonary large cell neuroendocrine carcinoma

Respiratory Medicine Case Reports
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an uncommon variant of non-small cell lung cancer (NSCLC), known for its aggressive behavior.
Tatsuru Eihuku, Seiichi Miwa, Tomoko Oshima, Hisano Ohba, Masahiro Shirai   +4 more
doaj   +2 more sources

Long‐Term Disease‐Free Survival After Systemic‐First Sequential Multimodal Therapy for Advanced and Recurrent Large‐Cell Neuroendocrine Carcinoma of the Uterine Cervix: A Case Report [PDF]

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 5, May 2026.
ABSTRACT Cervical large‐cell neuroendocrine carcinoma (LCNEC) is a rare and highly aggressive malignancy with poor prognoses, particularly in advanced or recurrent disease. We describe a case of advanced and recurrent cervical LCNEC in which long‐term disease‐free survival was achieved following a systemic‐first, sequential multimodal treatment ...
Kimio Wakana, Mayu Akita, Fumiko Tsubata, Yusuke Kori, Tamami Odai, Naoyuki Miyasaka   +5 more
wiley   +2 more sources

Advances of Treatment of Pulmonary Large Cell Neuroendocrine Carcinoma

Chinese Journal of Lung Cancer
Large cell neuroendocrine carcinoma (LCNEC) of lung is a rare neuroendocrine carcinoma subtype with difficulty in early diagnosis and poor prognosis which is treated with standard strategies of small cell lung cancer and non-small cell lung cancer.
Jiayi SUN, Yawan JING, Panwen TIAN, Weimin LI, Yalun LI   +4 more
doaj   +2 more sources

Advances in genetic profile and therapeutic strategy of pulmonary large cell neuroendocrine carcinoma [PDF]

Frontiers in Medicine
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine carcinoma (HGNEC) accounting for 3% of primary lung cancer, and characterized by strong invasion, high heterogeneity, and extremely poor prognosis.
Siyu Zhu, Xinyue Wang, Hui Li, Hui Li, Peiyan Zhao, Peiyan Zhao, Jingjing Liu, Liang Zhang, Ying Cheng, Ying Cheng, Ying Cheng   +10 more
doaj   +2 more sources

Pulmonary large-cell neuroendocrine carcinoma (LCNEC) [PDF]

European Journal of Cardio-Thoracic Surgery, 2003
The experiences on the treatment of seven consecutive patients with large-cell neuroendocrine carcinoma (LCNEC) were studied, observed over 6 years from 1992. Since LCNEC was recognized as a separate histological entity, only very few series have been reported. Together with the carcinoids (atypical and typical) and the small-cell lung carcinoma (SCLC),
René, Hage, Kees, Seldenrijk, Peter, de Bruin, Henry, van Swieten, Jules, van den Bosch   +4 more
openaire   +2 more sources

Long-term disease-free survivor of metastatic large-cell neuroendocrine carcinoma of the lung treated with amrubicin and irinotecan

Drug Design, Development and Therapy, 2009
Shinichiro Ryuge1, Shi-Xu Jiang2, Mayuko Wada1, Ken Katono1, Maiko Iwasaki1, Akira Takakura1, Sakiko Otani1, Yuka Kimura1, Tomoya Fukui1, Masanori Yokoba1, Masaru Kubota1, Masato Katagiri1, Kazusige Hayakawa3, Noriyuki Masuda11Department of Respiratory ...
Shinichiro Ryuge, Shi-Xu Jiang, Mayuko Wada, Ken Katono, et al.   +4 more
doaj   +1 more source