Results 31 to 40 of about 2,584,744 (346)

The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma

Clinical Cancer Research, 2019
Purpose: The optimal systemic treatment for pulmonary large-cell neuroendocrine carcinoma (LCNEC) is still under debate. Previous studies showed that LCNEC with different genomic characteristics might respond differently to different chemotherapy ...
M. Zhuo, Y. Guan, Xue Yang, L. Hong, Yuqi Wang, Zhongwu Li, Runzhe Chen, H. Abbas, Lianpeng Chang, Yuhua Gong, N. Wu, J. Zhong, Wenting Chen, Hanxiao Chen, Z. Dong, Xiang Zhu, Jianjie Li, Yuyan Wang, T. An, Mei-na Wu, Ziping Wang, Jiayin Wang, Emily B. Roarty, W. Rinsurongkawong, J. Lewis, J. Roth, S. Swisher, J. J. Lee, J. Heymach, I. Wistuba, N. Kalhor, Ling Yang, X. Yi, P. Futreal, B. Glisson, X. Xia, Jianjun Zhang, Jun Zhao   +37 more
semanticscholar   +1 more source

De novo large‐cell neuroendocrine carcinoma of the prostate: A case report and literature review

IJU Case Reports, 2022
Introduction Prostatic large‐cell neuroendocrine carcinoma is poorly studied. Although several case reports are available, information on the clinicopathological characteristics of this disease is limited, particularly for the de novo (hormone‐naive ...
Eri Fukagawa, Takeshi Yuasa, Kentaro Inamura, Kosuke Hamada, Motohiro Fujiwara, Yoshinobu Komai, Junji Yonese   +6 more
doaj   +1 more source

Primary large-cell neuroendocrine carcinoma of the prostate [PDF]

Archives of the Balkan Medical Union, 2022
Introduction. Depending on neuroendocrine differentiation, the prostate cancer is divided into two major groups: primary neuroendocrine prostate tumour (carcinoid, small-cell, and large-cell neuroendocrine carcinoma) or as a focal tumour in conventional ...
Spasimir T. SHOPOV
doaj   +1 more source

Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging. [PDF]

, 2018
The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue ...
Adams, Julia, Fisk, John C, Ghazal, Diala, Jessee, Joseph, Johnson, Holly, Karacosta, Loukia G, Koury, Steven, Ludwig, Rachel, Olson, James R, Rittenhouse-Olson, Kate, Roy, Rene, Sajjad, Munawwar, Tati, Swetha, Turner, Bradley   +13 more
core   +2 more sources

New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma

Molecular & Cellular Oncology, 2020
High-grade neuroendocrine lung carcinomas (LCNEC, SCLC) are recalcitrant cancers for which no optimal management has been achieved. We have recently described two models of LCNEC and SCLC developed upon inactivation of 4 tumor suppressors genes (Rb1 (RB ...
Mirentxu Santos
doaj   +1 more source

A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma [PDF]

, 2017
Aims: CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC) but neither this sensitivity nor specificity is absolute. This study is the first known comparison of CDX1 and A33 against CDX2 as immunomarkers for CRC.
Adamczyk, Lukasz A., Cullen, Jayne, Evans, Shanna, Oien, Karin A., Oniscu, Anca, Wong, Newton A.C.S.   +5 more
core   +1 more source

SOX11 is a sensitive and specific marker for pulmonary high-grade neuroendocrine tumors

Diagnostic Pathology, 2022
Background Synaptophysin (SYN), chromogranin A (CGA), CD56 and insulinoma-associated protein 1 (INSM1) are proposed neuroendocrine (NE) markers used for diagnosis of pulmonary NE tumors.
Lu Yu, Yuting Dong, Jin Xue, Sanpeng Xu, Guoping Wang, Dong Kuang, Yaqi Duan   +6 more
doaj   +1 more source

Immune checkpoint inhibitors in renal cell carcinoma [PDF]

, 2017
The immune system has long been known to play a critical role in the body's defence against cancer, and there have been multiple attempts to harness it for therapeutic gain.
Jones, Robert J., Ross, Kirsty
core   +1 more source

The demographic and treatment options for patients with large cell neuroendocrine carcinoma of the lung

Cancer Medicine, 2019
Lung large cell neuroendocrine carcinoma (L‐LCNEC) is a rare, aggressive tumor, for which the optimal treatment strategies for LCNEC have not yet been established.
Jianjun Gu, Daohui Gong, Yuxiu Wang, Beiyuan Chi, Jun Zhang, Suwei Hu, Lingfeng Min   +6 more
semanticscholar   +1 more source

Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens?

Histopathology, 2019
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimens.
J. Derks, A. Dingemans, R. V. van Suylen, M. D. den Bakker, R. Damhuis, E. C. van den Broek, E. Speel, E. Thunnissen   +7 more
semanticscholar   +1 more source