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Thyroid: Medullary carcinoma [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Medullary thyroid cancers (MTC) are rare neuroendocrine tumors arising from the parafollicular C-cells of the thyroid. In this review, we provide a general overview of the classification, pathology, and clinical management of MTC. In the latter half, we survey the underlying genetic framework of MTC and its potential implications within a diagnostic ...
Somnay, Y, Schneider, D, Mazeh, H
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Medullary Thyroid Carcinoma [PDF]
Scandinavian Journal of Surgery, 2004 Medullary thyroid carcinoma (MTC) is subdivided into sporadic (75%) and hereditary (25%) forms. Several germline mutations in the RET proto-oncogene are the source of distinct clinical phenotypes in hereditary MTC including familial MTC (FMTC) and multiple endocrine neoplasia 2A (MEN 2A) and 2B (MEN 2B).
M, Brauckhoff +5 more
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Medullary Carcinoma and Thyrocalcitonin [PDF]
BMJ, 1968 Seven patients with medullary carcinoma of the thyroid were investigated, and the thyrocalcitonin activity of the primary tumours, metastatic deposits, and the serum was estimated.Medullary carcinomas of the thyroid with amyloid stroma contain 100 to 600 times more thyrocalcitonin than normal thyroid tissue, and lymph nodes with metastatic deposits are
M, Tubiana +5 more
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Archives of Pathology & Laboratory Medicine, 2019 Renal medullary carcinoma, also referred to as the seventh sickle cell nephropathy, typically affects young African Americans with sickle cell trait, or, less frequently, patients with sickle cell disease. The existence of renal medullary carcinoma without a concomitant hemoglobinopathy is a topic of controversy.
Alexis, Elliott, Evelyn, Bruner
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Expert Review of Anticancer Therapy, 2023 Medullary thyroid carcinoma (MTC) constitutes approximately 5-10% of all thyroid cancers. Although the tumor forms in the thyroid, it doesn't originate from thyroid cells, but from the C cells or parafollicular cells which produce and release a hormone called calcitonin (CT). Starting from the second half of the 1900s, MTC was progressively studied and
Pelizzo, Maria Rosa +3 more
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Medullary carcinoma of the thyroid
Journal of British Surgery, 1969 A clinical study was conducted using histological slides of all cases diagnosed as carcinoma of the thyroid in the United Birmingham (England) Hospitals since 1940 and in the Regional Histological Collection from 1953-67. A total of 23 patients or 8% were found to have medullary carcinonma.
C R, Williams, D B, Brewer
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American Journal of Otolaryngology, 1993 Medullary thyroid carcinoma (MTC) comprises approximately 1–2% of thyroid malignancies and occurs in sporadic and heritable forms. Hereditary forms include multiple endocrine neoplasia (MEN) type 2A, familial medullary thyroid carcinoma (FMTC), and MEN type 2B.
Y L, Colson, S E, Carty
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Medullary Carcinoma of the Thyroid
Cancer Control, 2000 Medullary thyroid cancer (MTC) is a distinct C-cell tumor of the thyroid. We review the oncogenesis and management of both sporadic tumors and those tumors arising as part of specific inherited syndromes. The RET proto-oncogene plays a role in the development of inherited forms of MTC and has become important in the clinical management of patients and ...
G W, Randolph, D, Maniar
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Experimental oncology, 2008 ?????? ???????????????? ???????????? ???????????????? ???????????????? ???????????????????????????????? ???????????????????????????? ???????????????????????? ?????????? ????????????. ?????????????????????? ?????????????????? ???????????????? ???????????? (????????) ???????????????????????? ?????????? ?????? ?????????????????????? ???????? ??????????????
Malyuchik, S.S., Kiyamova, R.G.
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Imaging of Renal Medullary Carcinoma
Journal of Kidney Cancer and VHL, 2017 Renal medullary carcinoma (RMC) is a rare, highly aggressive tumor recognized as an independent pathological entity. African-descent adolescents and young adults with sickle cell hemoglobinopathy are the most affected groups. This rare subtype of renal cell carcinoma has its own morphogenetic and pathological characteristics.
Greco F +7 more
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