Results 51 to 60 of about 106,450 (263)

Medullary Carcinoma and Thyrocalcitonin [PDF]

BMJ, 1968
Seven patients with medullary carcinoma of the thyroid were investigated, and the thyrocalcitonin activity of the primary tumours, metastatic deposits, and the serum was estimated.Medullary carcinomas of the thyroid with amyloid stroma contain 100 to 600 times more thyrocalcitonin than normal thyroid tissue, and lymph nodes with metastatic deposits are
M, Tubiana, G, Milhaud, G, Coutris, J, Lacour, C, Parmentier, B, Bok   +5 more
openaire   +2 more sources

Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers [PDF]

, 2014
Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine threonine kinase belonging to the PIKK family (phosphoinositide 3-kinase-like-family of protein kinase), is a critical component of the non-homologous end joining (NHEJ ...
AC Wolff, Andrew R. Green, Arvind Arora, B Salles, C Curtis, Christina Perry, Devika Agarwal, Emad Rakha, ET Shinohara, FM Hsu, Graham Ball, HS Lee, HS Lee, Ian O. Ellis, JA Neal, K Meek, K Soderlund Leifler, L Du, LA Loeb, LA Loeb, LM McShane, M Burg van der, Nicola Thompson, Paul Moseley, R Hill, R Sultana, S Medunjanin, SJ Collis, SL Shao, Srinivasan Madhusudan, Stephen Chan, SY Wang, Tarek Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, U Moll, W Zhuang, X Kong, X Wang, XD Long, Z Hu   +41 more
core   +2 more sources

Medullary Carcinoma of the Gastrointestinal Tract: Report on Two Cases with Immunohistochemical and Molecular Features

Diagnostics, 2021
Medullary carcinoma of the colon is a rare histological variant characterized by a poorly differentiated morphology, an aberrant immunophenotype, and microsatellite instability.
Cristina Colarossi, Marzia Mare, Giorgio La Greca, Marco De Zuanni, Lorenzo Colarossi, Eleonora Aiello, Eliana Piombino, Lorenzo Memeo   +7 more
doaj   +1 more source

Pediatric Medullary Thyroid Carcinoma [PDF]

Journal of Pediatric Oncology, 2016
Medullary thyroid carcinoma (MTC), which originates from thyroid parafollicular C cells, accounts for 3 to 5% of thyroid malignancies. MTC occurs either sporadically or in an inherited autosomal dominant manner. Hereditary MTC occurs as a familial MTC or as a part of multiple endocrine neoplasia (MEN) type 2A and B syndromes.
Starenki, Dmytro, Park, Jong-In
openaire   +2 more sources

Unmodifiable variables related to thyroid cancer incidence [PDF]

, 2018
The incidence of thyroid cancer is significantly different between male and female patients. Thyroid cancer is also the only form of cancer where age can be considered a staging variable.
Alecu, Lucian, Hainarosie, Razvan, Jecan, Radu C., Nitipir, Cornelia, Orlov, Cristina, Pituru, Silviu, Slavu, Iulian, Stanculeanu, Dana L., Stoian, Anca P., Tulin, Adrian, Tulin, Raluca   +10 more
core   +2 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Medullary thyroid carcinoma with double negative calcitonin and CEA: a case report and update of literature review

BMC Endocrine Disorders, 2019
Background Medullary thyroid carcinoma is a malignant uncommon and aggressive tumour of the parafollicular C cells. In about 75% of cases it is sporadic while, in case of RET mutation, it is associated to multiple endocrine neoplasia type 2 (25% of cases)
Claudio Gambardella, Chiara Offi, Guglielmo Clarizia, Roberto Maria Romano, Immacolata Cozzolino, Marco Montella, Rosa Maria Di Crescenzo, Massimo Mascolo, Angelo Cangiano, Sergio Di Martino, Giancarlo Candela, Giovanni Docimo   +11 more
doaj   +1 more source

Acoustic radiation force impulse imaging for differentiation of thyroid nodules [PDF]

, 2012
Background: Acoustic Radiation Force Impulse (ARFI)-imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness.
Berner, Christian, Bojunga, Jörg, Dauth, Nina, Friedrich-Rust, Mireen, Herrmann, Eva, Holzer, Katharina, Meyer, Gesine, Schroeter, Hartmut, Voelkl, Lisa, Zeuzem, Stefan   +9 more
core   +3 more sources

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Calcitonin negative Medullary Thyroid Carcinoma: a challenging diagnosis or a medical dilemma?

BMC Endocrine Disorders, 2019
Background Medullary thyroid carcinoma is a neuroendocrine tumor belonging form a malignant growth of the thyroid parafollicular C-cells, representing from 1 to 10% of all thyroid cancer.
Claudio Gambardella, Chiara Offi, Renato Patrone, Guglielmo Clarizia, Claudio Mauriello, Ernesto Tartaglia, Francesco Di Capua, Sergio Di Martino, Roberto Maria Romano, Lorenzo Fiore, Alessandra Conzo, Giovanni Conzo, Giovanni Docimo   +12 more
doaj   +1 more source