Results 221 to 230 of about 104,892 (304)

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 85-99, June 2026.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Primary small cell neuroendocrine carcinoma of the liver: a case report. [PDF]

Discov Oncol
Yin S, Li S, Zhang L.
europepmc   +1 more source

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

Mechanistic insights and molecular therapy for neuroendocrine prostate cancer. [PDF]

Front Oncol
Niu Y, Zhang S, Zhang S, Tao J, Zhu Y.
europepmc   +1 more source

Patients With Stage III PLCNEC Advocated for Radiotherapy Combined With Chemotherapy While With Stage IV Focus on Individualized Management: Evidence From SEER

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background PLCNEC is a rare and highly aggressive lung cancer with a poor prognosis. Multimodal therapy, primarily chemotherapy‐based, is the standard for advanced PLCNEC, but the role of radiotherapy remains unclear. Methods We analyzed 1086 PLCNEC patients receiving chemotherapy from the Surveillance, Epidemiology, and End Results (SEER ...
Yuze Zhao, Guantong Liu, Haitao Li, Yu Li, Ting Lin, Zefeng Xie   +5 more
wiley   +1 more source

Silent Aggressor: Unveiling Large-Cell Duodenal Neuroendocrine Carcinoma. [PDF]

Cureus
Sheth S, Punatar S, Spyratos T.
europepmc   +1 more source

Metachronous Primary Pancreatic Neuroendocrine Tumor and Adenocarcinoma: A Case Report

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with most patients presenting with advanced disease. Surgical resection remains the only potentially curative option, yet recurrence rates are high. Case We present a rare case of metachronous primary pancreatic neuroendocrine tumor (PanNET) and PDAC in a 71‐year‐old ...
Anastasia S. Fatyanova, Maria E. Kalinina, Dina F. Islamova, Igor O. Shchekoturov, Julia V. Lerner, Nadezhda A. Stashevskaya, Pavel Burko, Ilias Miltiadis   +7 more
wiley   +1 more source

Integrated transcriptomic and proteomic validation identifies SLC35D3 as a tumor-selective surface antigen for colorectal and neuroendocrine carcinomas. [PDF]

Biochem Biophys Rep
Someya S, Inoue T, Kawaida R, Ohtsuka T, Fukuchi K.   +4 more
europepmc   +1 more source

Sensing and Communicating β‐Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Type 1 diabetes (T1D) results from the immune‐mediated destruction of insulin‐producing pancreatic β‐cells. Recent human studies show that early β‐cell stress maladaptations precede overt immune cell infiltration. DOC2B, a vesicle secretion regulatory protein that supports β‐cell functionality and resilience against stress, declines early in T1D ...
Diana Esparza, Chathurani S. Jayasena, Tijana Jovanovic‐Talisman, Debbie C. Thurmond   +3 more
wiley   +1 more source

Neuroendocrine Tumors of the Gallbladder: A Multicenter Case Series and Systematic Literature Review Indicating Predominantly Non-Aggressive Tumor Behavior and a Common Association with Cholesterol Polyps and Cholesterolosis. [PDF]

Endocr Pathol
Vanoli A, Xue Y, Kasajima A, Ruffoni R, Tarcan ZÇ, Tezcan N, Liu X, Navale P, Mohamed A, Gullo I, Silva R, Vocino Trucco G, Volante M, Disanto MG, Taverna C, Kuzucular E, Luchini C, Roa JC, Esposito I, La Rosa S, Pehlivanoglu B, Reid M, Klöppel G, Basturk O, Adsay V.   +24 more
europepmc   +1 more source