Results 121 to 130 of about 689,752 (349)

The Robustness of Pathway Analysis in Identifying Potential Drug Targets in Non-Small Cell Lung Carcinoma [PDF]

, 2014
The identification of genes responsible for causing cancers from gene expression data has had varied success. Often the genes identified depend on the methods used for detecting expression patterns, or on the ways that the data had been normalized and ...
Aguilar-Ruiz, Croft, Garnier, González-Barón, Ihaka, Knudsen, Perez-Moreno, Polakis, Smyth, Stekel, Wang, Weinberg, Yu   +12 more
core   +2 more sources

Expression and significance of SOX2 in non-small cell lung carcinoma

Oncology Letters, 2016
The aim of the present study was to examine the expression and clinical significance of SOX2 in non-small cell lung carcinoma (NSCLC). Immunohistochemistry was used to detect the expression level of SOX2 in 127 cases of NSCLC. The Chi-square test was used to analyze the association of SOX2 expression and clinicopathological factors in NSCLC and para ...
Jie Ying, Chuan‑Sheng Li, Chao Shi, Wei‑Dong Zhang, Li‑Ping Hu   +4 more
openaire   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Two Cases of TKI-resistant Small Cell Lung Cancer Transformation 
in Advanced Adenocarcinoma and Literature Review

Chinese Journal of Lung Cancer, 2022
Treatment of advanced non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) can achieve good disease control, but it will inevitably produce drug resistance ...
Jieqiong WU, Dunqiang REN, Bingqian YI, Huanhuan BI, Yanmei SHAO, Hongmei WANG   +5 more
doaj   +1 more source

Interpretable Prediction of Lung Squamous Cell Carcinoma Recurrence With Self-supervised Learning [PDF]

Proceedings of The 5th International Conference on Medical Imaging with Deep Learning, PMLR 172:1504-1522, 2022, 2022
Lung squamous cell carcinoma (LSCC) has a high recurrence and metastasis rate. Factors influencing recurrence and metastasis are currently unknown and there are no distinct histopathological or morphological features indicating the risks of recurrence and metastasis in LSCC.
arxiv  

Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives [PDF]

, 2014
Coprinopsis atramentaria is a wild edible mushroom whose methanolic extract revealed a marked antioxidant activity; p-hydroxybenzoic (HA), p-coumaric (CoA) and cinnamic (CA) acids were identified in the extract. In the present work, the cytotoxicity of C.
Calhelha, Ricardo C., Esteves, Ana P., Ferreira, Isabel C.F.R., Heleno, Sandrina A., Martins, Anabela, Queiroz, Maria João R.P.   +5 more
core   +1 more source

Defining target volumes for non-small cell lung carcinoma

Seminars in Radiation Oncology, 2004
The definition of target volumes for non-small cell lung carcinoma (NSCLC) remains a controversial topic as tradition-based approaches of the past are being critically re-evaluated in the light of the advent of three-dimensional treatment techniques, by the awareness of the poor local control achieved using current treatment fields and radiation doses,
Senan, Suresh, Chapet, Olivier, Lagerwaard, Frank J., Ten Haken, Randall K.   +3 more
openaire   +4 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

EGFR mutation testing in non-small cell lung cancer (NSCLC)

Journal of Infection and Public Health, 2012
Summary: Lung carcinoma is subdivided into small cell carcinoma and non-small cell carcinoma (NSCLC). NSCLC is heterogeneous group of carcinomas and accounts for 70–80% of lung cancer. NSCLC is further divided into adenocarcinoma, squamous cell carcinoma,
Fouad Al Dayel
doaj  

Clinicopathological and Immunohistochemical Analysis of Lung Cancer Biopsies at a Tertiary Care Centre in Central Gujarat, India [PDF]

National Journal of Laboratory Medicine
Introduction: Lung biopsy is a reliable and highly accurate tool for diagnosing and subtyping lung lesions. Two-thirds of lung cancer patients present with advanced disease, and small biopsies remain the main diagnostic tool.
Yogita Vrajlal Kareliya, Neema Ankur Rana, Srilakshmi Premnath Hiryur, Helly Dilipbhai Patel, Roshni Ashokbha Patel, Samiksha Raosaheb Shindegalwekar   +5 more
doaj   +1 more source