Results 111 to 120 of about 19,522,173 (311)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Comparison Study of Cyfra 21-1, Carcinoembryonic Antigen and Telomerase Activity between Non Small Cell and Small Cell Lung Cancer Patients

پزشکی بالینی ابن سینا, 2008
Introduction & Objective: The roles of tumor markers in the prognosis and diagnosis of lung cancer is under investigation. The aim of this study was to examine correlation between serum levels of Carcinoembryonic Antigen (CEA) and Cyfra 21-1 with ...
Behrang Alani, Khalil Ansarin, Mohammad Javad Selmizadeh, Ebrahim Cheraghi   +3 more
doaj  

Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy

Frontiers in Oncology
Lung cancer remains the leading cause of cancer-related mortality, with 1.8 million deaths per year. Small cell lung cancer and non-small cell lung cancer (NSCLC) are the main cancer types.
Quanqing Li, Guangxin Zhang, Hao Yang, Jindong Li   +3 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Nucleosomes indicate the in vitro radiosensitivity of irradiated bronchoepithelial and lung cancer cells [PDF]

, 2004
Nucleosomes, which are typical cell death products, are elevated in the serum of cancer patients and are known to rapidly increase during radiotherapy.
Mitlewski, Anke, Holdenrieder, Stefan, Bergner, Albrecht, Gamarra, Fernando, Huber, Rudolf M., Stief, Jutta, Stieber, Petra, Nagel, Dorothea   +7 more
core   +1 more source

Prognostic impact of c-MYC and EZH2 expression in small cell and non-small cell lung carcinoma: a single-center retrospective study

Discover Oncology
Background c-MYC and enhancer of zeste homolog 2 (EZH2) are key regulators of cell proliferation and epigenetic reprogramming and have been implicated in the pathogenesis and progression of lung carcinoma.
Berkan Karadurmuş, Emel Sezer, Rabia Bozdoğan Arpacı, Kadir Eser, Semra Erdoğan, Vehbi Erçolak   +5 more
doaj   +1 more source

Clinicopathological and immunohistochemical profile of non-small cell lung carcinoma in a tertiary care medical centre in South India

Lung India, 2014
Background: Lung cancer is a highly aggressive malignancy causing high morbidity and mortality. An increasing incidence of lung cancer has been observed in India.
Shanmugapriya Shankar, Vijayalakshmi Thanasekaran, T Dhanasekar, Prathiba Duvooru   +3 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

A Rare Case of Non-Small Cell Carcinoma of Lung Presenting as Miliary Mottling

Iranian Journal of Medical Sciences, 2013
Miliary mottling on chest radiography is seen in miliary tuberculosis, certain fungal infections, sarcoidosis, coal miner’s pneumoconiosis, silicosis, hemosiderosis, fibrosing alveolitis, acute extrinsic allergic alveolitis, pulmonary eosinophilic ...
Ballaekere Jayaram Subhashchandra, Mohammed Ismailkhan, Kuppegala Chikkaveeraiah Shashidhar, Moda Gopalakrishna Narahari   +3 more
doaj