Results 91 to 100 of about 19,522,173 (311)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Microvessel density as a prognostic factor in non-small-cell lung carcinoma: a meta-analysis of individual patient data.

, 2007
BACKGROUND: Angiogenesis is a potential prognostic factor that has been investigated in patients with non-small-cell lung carcinoma. However, published studies of the role of angiogenesis as a prognostic factor are inconclusive.
Prognosis In Lung Cancer (PILC) Collaborative Study Group, Trivella, Marialena, Trivella, M, Altman, Douglas G, Harris, Adrian L, Pastorino, U, Trivella, Maria-Heleni, Altman, DG, Pezzella, Francesco, Altman, Douglas G., Pastorino, Ugo, Harris, Adrian L., Harris, AL, Pezzella, F   +13 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Atypical Presentation of Non-small Cell Lung Carcinoma

Cureus
The typical presentation of non-small cell lung carcinoma (NSCLC) is hemoptysis, dyspnea, and chest pain. A late cancer diagnosis commonly leads to the patient presenting with metastasis to the bone, liver, adrenal glands, or brain. We present a 58-year-old man who visited the emergency department with a headache for two weeks.
Jan, Ammaar, Sohal, Oudhay S, Pourkalbassi, Delaram, Boisson, Desiree, Taylor, Nick, Rivera, Lorena, Metelus, Ernest, Casadesus, Damian   +7 more
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer [PDF]

, 2001
BACKGROUND: The incidence of lung cancer is declining following a drop in smoking rates, but it is still the leading cause of death from cancer in England and Wales, with about 30,000 deaths a year.
A. Clegg, N. Waugh, D. A. Scott, M. Sidhu, Waugh, N, Clegg, A. J., Scott, David A., Waugh, Norman, Clegg, A, Hewitson, P., Hewitson, P, Scott, D A, Sidhu, M, Sidhu, M. K., P. Hewitson   +14 more
core   +1 more source

Tumor suppressor miR-29c regulates radioresistance in lung cancer cells

Tumor Biology, 2017
Radiotherapy is an important treatment option for non-small cell lung carcinoma patients. Despite the appropriate use of radiotherapy, radioresistance is a biological behavior of cancer cells that limits the efficacy of this treatment.
Elena Arechaga-Ocampo, Cesar Lopez-Camarillo, Nicolas Villegas-Sepulveda, Claudia H Gonzalez-De la Rosa, Isidro X Perez-Añorve, Reynalda Roldan-Perez, Ali Flores-Perez, Omar Peña-Curiel, Oscar Angeles-Zaragoza, Rosalva Rangel Corona, Juan A Gonzalez-Barrios, Raul Bonilla-Moreno, Oscar del Moral-Hernandez, Luis A Herrera, Alejandro Garcia-Carranca   +14 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck [PDF]

, 2008
Introduction: Gefitinib, an orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces growth arrest in squamous cancer cell carcinoma of head and neck (SCCHN) cell lines mainly by blocking cells in G1 and preventing them ...
Romano, Carmela
core   +1 more source

Submicron silica particles have cytotoxicities on hepatocellular carcinoma, non-small cell lung cancer and breast cancer by unified regulating the XLOC_001659/miR-98-5p/MAP3K2-mediated pathway. [PDF]

Toxicol Res (Camb), 2021
Shi J, Ci Y, Zheng Y, Chen W, Chen X.
europepmc   +1 more source