Results 131 to 140 of about 689,752 (349)

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Nature Communications, 2019
Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and stimulates antitumor immune responses. Here we unravel the results of an unbiased screen identifying high-dose (10 µM) crizotinib as an ICD-inducing tyrosine kinase ...
Peng Liu, Liwei Zhao, Jonathan G. Pol, Sarah Lévesque, Adriana Petrazzuolo, C. Pfirschke, Camilla Engblom, S. Rickelt, T. Yamazaki, Kristina Iribarren, L. Senovilla, Lucillia Bezu, Erika Vacchelli, V. Sica, Andréa Melis, Tiffany Martin, Lin Xia, H. Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Déborah Lefevre, S. Broutin, A. Paci, A. Bongers, V. Minard-Colin, E. Tartour, L. Zitvogel, L. Apetoh, Yuting Ma, M. Pittet, O. Kepp, G. Kroemer   +33 more
semanticscholar   +1 more source

Changes on Mitochondrial DNA Content in Non-small Cell Lung Cancer [PDF]

, 2011
Background and objective It has been proven that the mitochondrial DNA (mtDNA) mutations and content change were associated with increasing risk of tumorigenesis. MtDNA content is significantly reduced in most substantive tumors. The aim of this study is
Hongmei WANG, Jigang DAI
core  

Perioperative detection of circulating tumour cells in patients with lung cancer [PDF]

, 2017
© 2017 Chudasama et al. Lung cancer is a leading cause of mortality and despite surgical resection a proportion of patients may develop metastatic spread.
Alexandra Rice, Cohen, Cristofanilli, Delloye-Bourgeois, Desitter, Dimple Chudasama, Emmanouil Karteris, Fidler, Fidler, Hashimoto, Hayes, Hiltermann, Hou, Julie Beeson, Karl, Krebs, Krebs, Lee, Munzone, Nagrath, Nathan Burnside, Scheinin, Vladimir Anikin, Yao, Zhang   +24 more
core   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Giant cell carcinoma of the lung successfully treated with surgical resection and adjuvant vinorelbine and cisplatin [PDF]

, 2018
© 2018 Giant Cell Carcinoma of the lung, a subtype of Sarcomatoid lung cancer is a poorly differentiated Non-Small-Cell Lung Cancer. GCCL has exceptionally aggressive characteristics, and its prognosis is much poorer than any other NSCLCs.
Azam, M., Chalhoub, M., Habib, S., Leifer, L. E., Rajdev, K., Siddiqui, A. H.   +5 more
core   +3 more sources

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Tumor suppressor miR-29c regulates radioresistance in lung cancer cells

Tumor Biology, 2017
Radiotherapy is an important treatment option for non-small cell lung carcinoma patients. Despite the appropriate use of radiotherapy, radioresistance is a biological behavior of cancer cells that limits the efficacy of this treatment.
Elena Arechaga-Ocampo, Cesar Lopez-Camarillo, Nicolas Villegas-Sepulveda, Claudia H Gonzalez-De la Rosa, Isidro X Perez-Añorve, Reynalda Roldan-Perez, Ali Flores-Perez, Omar Peña-Curiel, Oscar Angeles-Zaragoza, Rosalva Rangel Corona, Juan A Gonzalez-Barrios, Raul Bonilla-Moreno, Oscar del Moral-Hernandez, Luis A Herrera, Alejandro Garcia-Carranca   +14 more
doaj   +1 more source

Using Apple Machine Learning Algorithms to Detect and Subclassify Non-Small Cell Lung Cancer [PDF]

arXiv, 2018
Lung cancer continues to be a major healthcare challenge with high morbidity and mortality rates among both men and women worldwide. The majority of lung cancer cases are of non-small cell lung cancer type. With the advent of targeted cancer therapy, it is imperative not only to properly diagnose but also sub-classify non-small cell lung cancer. In our
arxiv  

American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003.

Journal of Clinical Oncology, 2004
The American Society of Clinical Oncology (ASCO) previously published evidencebased guidelines for the treatment of unresectable non–small-cell lung cancer (NSCLC) [1].
D. Pfister, David H. Johnson, C. Azzoli, W. Sause, Thomas J. Smith, Sherman Baker, J. Olak, D. Stover, John R. Strawn, A. Turrisi, M. Somerfield   +10 more
semanticscholar   +1 more source

Lung cancer: risk factors, management, and prognosis [PDF]

, 2016
Lung cancer or lung tumor the most common cause of cancer death in men and second most common in women after breast cancer. Highest rates in North America, Europe, and East Asia, with one third of new cases in China, lower rates in Africa and South Asia.
A. Nazirah, AM, Sharifa, AR. Jamalul Azizi, EL. IIIzam, Murtaza Mustafa, SA. Abbas   +5 more
core   +1 more source