Results 131 to 140 of about 615,884 (310)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Upregulation of OTUD7B (Cezanne) Promotes Tumor Progression via AKT/VEGF Pathway in Lung Squamous Carcinoma and Adenocarcinoma

Frontiers in Oncology, 2019
OTUD7B, a multifunctional deubiquitinylase, plays an essential role in inflammation and proliferation signals. However, its function in lung cancer remains largely unknown.
Dan-dan Lin, Yang Shen, Shu Qiao, Wen-wen Liu, Lishuang Zheng, Ya-nan Wang, Naipeng Cui, Yun-fan Wang, Shuli Zhao, Jian-hong Shi   +9 more
doaj   +1 more source

Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma

Lung Cancer: Targets and Therapy, 2017
The treatment options for metastatic non-small-cell lung cancer (NSCLC) have expanded dramatically in the last 10 years with the discovery of newer drugs and targeted therapy. Epidermal growth factor receptor (EGFR), when aberrantly activated, promotes cell growth and contributes in various ways to the malignant process.
Thakur,Manish, Wozniak,Antoinette
openaire   +4 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Advances in combined neuroendocrine carcinoma of lung cancer

Pathology and Oncology Research
Lung cancer incidence and mortality rates are increasing worldwide, posing a significant public health challenge and an immense burden to affected families.
Zesen Han, Fujun Yang, Fang Wang, Huayu Zheng, Xiujian Chen, Hongyu Meng, Fenglei Li   +6 more
doaj   +1 more source

Determination of safe margin in the surgical pathologic specimens of non-small cell carcinoma of the lung [PDF]

Background and Aim: Local recurrences of the tumor at the surgical margin are serious problems in pulmonary resections for lung cancer. The aim of this study is to determine the involved margins and safe distances of the resection sites from tumor for ...
رحیمی راد, محمدحسین, سکوتی, محسن, فرحناک, محمدرضا, فیضی, ایرج, قوجازاده, مرتضی, هاشم زاده, شهریار, گلزاری, صمد   +6 more
core  

Atypical Presentation of Non-small Cell Lung Carcinoma

Cureus
The typical presentation of non-small cell lung carcinoma (NSCLC) is hemoptysis, dyspnea, and chest pain. A late cancer diagnosis commonly leads to the patient presenting with metastasis to the bone, liver, adrenal glands, or brain. We present a 58-year-old man who visited the emergency department with a headache for two weeks.
Jan, Ammaar, Sohal, Oudhay S, Pourkalbassi, Delaram, Boisson, Desiree, Taylor, Nick, Rivera, Lorena, Metelus, Ernest, Casadesus, Damian   +7 more
openaire   +2 more sources

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Clinical and Computed Tomography Characteristics for Early Diagnosis of Peripheral Small-cell Lung Cancer

Cancer Management and Research, 2022
Xiaochuan Zhang,1,2,* Fajin Lv,1,* Binjie Fu,1 Wangjia Li,1 Ruiyu Lin,1 Zhigang Chu1 1Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Radiology,
Zhang X, Lv F, Fu B, Li W, Lin R, Chu Z
doaj  

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source