Results 141 to 150 of about 361,742 (335)

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Prognostic Significance of Log(CA125)/PCI for the Resectability of Epithelial Ovarian Cancer: A Retrospective Study

Cancer Management and Research, 2020
Can He,1 Niresh Thapa,1,2 Yang Wang,1 Ziye Song,1 Jing Yang,1 Mengfei Xu,1 Na Zuo,1 Hongbing Cai1 1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological ...
He C, Thapa N, Wang Y, Song Z, Yang J, Xu M, Zuo N, Cai H   +7 more
doaj  

BRCA mutation in high grade epithelial ovarian cancers

Gynecologic Oncology Reports, 2019
Objective: To identify the frequency of BRCA mutation in patients with high grade epithelial ovarian cancer (EOC). Methods: Patients with EOC included fallopian tube cancer or peritoneal cancer with high grade serous or high grade endometrioid were ...
Tarinee Manchana, Natacha Phoolcharoen, Patou Tantbirojn   +2 more
doaj   +1 more source

Modeling the growth of multicellular cancer spheroids in a\ud bioengineered 3D microenvironment and their treatment with an\ud anti-cancer drug [PDF]

, 2010
A critical step in the dissemination of ovarian cancer cells is the formation of multicellular spheroids from cells shed from the primary tumor.
Byrne, H. M., Clements, J. A., Flegg, J. A., Hall, C. L., Hutmacher, D. W., Loessner, D., McElwain, D. L. S., Moroney, T. J.   +7 more
core  

ELF5 in epithelial ovarian carcinoma tissues and biological behavior in ovarian carcinoma cells

Oncology Reports, 2017
The expression of E74-like factor 5 (ELF5) in epithelial ovarian carcinoma tissues and its effects on biological behavior in ovarian carcinoma cells were assessed in search for a new approach for gene treatment of epithelial ovarian carcinoma. RT-PCR technology was applied to detect the expression of ELF5 mRNA in epithelial ovarian carcinoma (n=49 ...
Yan, Hongchao, Qiu, Linglin, Xie, Xiaolei, Yang, He, Liu, Yongli, Lin, Xiaoman, Huang, Hongxiang   +6 more
openaire   +3 more sources

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

P53 marker expression in epithelial ovarian tumours in a centre in Nigeria – a descriptive study

BMC Women's Health
Background p53 is a tumor suppressor gene. p53 expression in epithelial ovarian tumors (EOTs) is correlated with their biological behavior and predicts patient overall survival.
Andrew Olushola Anjorin, Olaejirinde Olaniyi Olaofe, Atinuke Olu Anjorin, Ganiat Olutoyin Omoniyi-Esan, Akinwumi Oluwole Komolafe   +4 more
doaj   +1 more source

CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways

Oncology Report, 2017
The degree of peritoneal dissemination and chemotherapy-resistant tumors is related to the prognosis in patients with advanced-stage ovarian cancer. The epithelial-mesenchymal-transition (EMT) is a multifaceted pathological program that endows cancer ...
Kiyoko Nakamura, Y. Terai, Akiko Tanabe, Y. Ono, M. Hayashi, K. Maeda, S. Fujiwara, Keisuke Ashihara, Michihiko Nakamura, Yoshimichi Tanaka, Tomohito Tanaka, Satoshi Tsunetoh, H. Sasaki, M. Ohmichi   +13 more
semanticscholar   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, Accepted Article.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source