Results 221 to 230 of about 63,783 (265)

Insulin resistance is associated with the aggressiveness of pancreatic ductal carcinoma

Acta Diabetologica, 2016
To study whether insulin resistance accelerates the development and/or the progression of pancreatic adenocarcinoma (PDAC), we hypothesized that patients with insulin resistance, compared with those without insulin resistance, show: (1) a younger age and more advanced PDAC stage at diagnosis and (2) a shorter disease-free and overall survival after ...
Dugnani E, Balzano G, Pasquale V, Scavini M, Aleotti F, Liberati D, Di Terlizzi G, Gandolfi A, Petrella G, Reni M, DOGLIONI , CLAUDIO, BOSI , EMANUELE, FALCONI, MASSIMO, PIEMONTI, LORENZO   +13 more
openaire   +4 more sources

Retroviral expression screening of oncogenes in pancreatic ductal carcinoma

European Journal of Cancer, 2005
Pancreatic ductal carcinoma (PDC) remains one of the most intractable malignancies in humans. In order to clarify the molecular events underlying the carcinogenesis in PDC, we constructed a retroviral cDNA expression library from a PDC cell line, and used it to screen transforming genes in PDC by a focus formation assay with mouse 3T3 fibroblasts.
Hiroyuki, Kisanuki, Young Lim, Choi, Tomoaki, Wada, Ryozo, Moriuchi, Shin-Ichiro, Fujiwara, Ruri, Kaneda, Koji, Koinuma, Madoka, Ishikawa, Shuji, Takada, Yoshihiro, Yamashita, Hiroyuki, Mano   +10 more
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Prognostic factors in the operative treatment of ductal pancreatic carcinoma

Langenbeck's Archives of Surgery, 2000
The average 5-year survival rate following resection of a ductal adenocarcinoma of the pancreas is 10%, worldwide. Despite increasing resection rates, only about 20% can be operated on with curative intent. A differential histopathological analysis of the resected tumors may help to justify expanding the surgical procedure by extended lymph-node ...
C, Gebhardt, W, Meyer, M, Reichel, P H, Wünsch   +3 more
openaire   +2 more sources

Mixed ductal–pancreatic polypeptide‐cell carcinoma of the pancreas

Histopathology, 2002
Mixed ductal–pancreatic polypeptide‐cell carcinoma of the pancreasAims:  Mixed ductal‐endocrine carcinomas of the pancreas are rare tumours with 10 cases reported in the English literature. We report the first case with a polypeptide‐cell component.Methods and results:  The tumour was fortuitouslydiscovered in a 72‐year‐old woman during the exploration
D, Chatelain, Y, Parc, S, Christin-Maitre, R, Parc, J-F, Flejou   +4 more
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[On the subject of pancreatic ductal carcinoma].

La Clinica terapeutica, 1999
Pancreatic cancer is a dismal disease. The 5-year overall survival ranges from 1% to 5%. Surgery is the only curative treatment available for this cancer, but it is indicated only in selected patients with a less than 4 cm tumor. In these patients, survival rate is about 30%.
D, Pantalone, M, Bontà, A, Allocca, M, Nincheri, A, Borri   +4 more
openaire   +1 more source

Centrosome abnormalities in pancreatic ductal carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
The centrosome plays an important role in microtubule nucleation and organization, ensuring the establishment of cell polarity and balanced chromosome segregation. Recent studies have suggested that the loss of cell polarity and/or chromosome missegregation (aneuploidy) in human malignant tumors could result from defects in centrosome function.
N, Sato, K, Mizumoto, M, Nakamura, K, Nakamura, M, Kusumoto, H, Niiyama, T, Ogawa, M, Tanaka   +7 more
openaire   +1 more source

The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: Insights for clinicians

Current Gastroenterology Reports, 2004
The phenotypic classification of pancreatic neoplasms is based on their cellular lineage. Thus, tumors with a ductal, acinar, and endocrine phenotype can be distinguished. Most pancreatic neoplasms show a ductal phenotype and can be classified as ductal adenocarcinomas.
Günter, Klöppel, Jutta, Lüttges
openaire   +2 more sources

Surgical treatment of ductal pancreatic carcinoma.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1991
Among 587 patients with ductal pancreatic carcinoma who were examined between 1969 and 1987, 260 (44.3%) had distant metastases at the time of diagnosis. Tumour resections, mostly subtotal duodenopancreatectomies, were performed in 138 patients (23.5% of all patients, or 39.8% of all patients without distant metastases); in 91 patients the resection ...
F P, Gall, H, Kessler, P, Hermanek
openaire   +1 more source

Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma

International Journal of Oncology, 2002
Pancreatic cancer is a malignant tumor with an extremely poor prognosis. Thrombospondin-1 (TSP-1) was suggested to be a potential regulator of tumor growth and metastasis. We examined TSP-1 expression in 77 cases of invasive ductal adenocarcinoma of the pancreas, and analyzed the correlation between the TSP-1 expression pattern and clinicopathological ...
Kosuke, Tobita, Hiroshi, Kijima, Shoichi, Dowaki, Yasuhisa, Oida, Hiroyuki, Kashiwagi, Masanori, Ishii, Yoshinori, Sugio, Takafumi, Sekka, Yasuo, Ohtani, Makiko, Tanaka, Sadaki, Inokuchi, Hiroyasu, Makuuchi   +11 more
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BRANCH DUCT ORIGIN OF SOLID TYPE PANCREATIC DUCTAL CARCINOMA

Australian and New Zealand Journal of Surgery, 1993
A case of branch duct origin of solid type pancreatic ductal carcinoma is presented. Stepwise tissue sections of an entire specimen, including the carcinoma area, and mapping, with special reference to the relationship between the main duct and the carcinoma area, were performed. Carcinoma cells of the branch duct showed intraductal spread with minimal
K, Furuta, S, Ikeda, H, Watanabe, Y, Kuroda, K, Maeshiro, R, Miyazaki   +5 more
openaire   +2 more sources