Results 231 to 240 of about 64,621 (307)

Ultrasonographic and Endoscopic Findings of Pancreatic Adenocarcinoma With Duodenal Invasion in a Brown Bear (Ursus arctos)

open access: yesVeterinary Radiology &Ultrasound, Volume 67, Issue 4, July 2026.
ABSTRACT This report describes a 25‐year‐old, intact male brown bear (Ursus arctos) presenting with weight loss, diarrhea, melena, apathy, and a 12% hematocrit. Ultrasound showed proximal duodenal wall thickening with submucosal cysts and a large, heterogeneous, highly vascularized mass in the descending duodenum, containing small gas pockets and ...
Mariana Giendruczak de Souza   +8 more
wiley   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo   +14 more
wiley   +1 more source

Remote robot-assisted pancreatoduodenectomy for one patient with pancreatic ductal adenocarcinoma. [PDF]

open access: yesHepatobiliary Surg Nutr
Huang CS   +5 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

open access: yesAdvanced Science, Volume 13, Issue 33, 15 June 2026.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu   +8 more
wiley   +1 more source

Spatial Analysis of Intraductal Papillary Mucinous Neoplasms Defines a Paradoxical Keratin 17-Positive, Low-Grade Epithelial Population Harboring Malignant Features. [PDF]

open access: yesCell Mol Gastroenterol Hepatol
Li J   +22 more
europepmc   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

open access: yesAdvanced Science, Volume 13, Issue 33, 15 June 2026.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun   +5 more
wiley   +1 more source

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
Accurate prediction of early recurrence in pancreatic ductal adenocarcinoma is vital for optimizing treatment. A novel, integrated radiomics‐pathology machine learning model successfully forecasts recurrence risks by analyzing preoperative CT images and computational pathology.
Sihang Cheng   +17 more
wiley   +1 more source

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