Results 41 to 50 of about 186,446 (142)

Expression of Calretinin, Marker of Mesothelial Differentiation, in Pancreatic Ductal Adenocarcinoma: A Potential Diagnostic Pitfall

Türk Patoloji Dergisi, 2021
Objective: Pancreatic ductal adenocarcinoma is one of the most common causes of "peritoneal carcinomatosis" and has an insidious growth pattern.
Gokce ASKAN, Olca BASTURK
doaj   +1 more source

The Emergence of TRP Channels Interactome as a Potential Therapeutic Target in Pancreatic Ductal Adenocarcinoma

Biomedicines, 2023
Integral membrane proteins, known as Transient Receptor Potential (TRP) channels, are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes ...
Yuanyuan Wei, Ahmad Taha Khalaf, Cao Rui, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Zahraa Oglah   +5 more
doaj   +1 more source

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

Journal of Experimental Medicine, 2017
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance, which enables disease to progress unabated by adaptive immunity.
Donnele Daley, Vishnu R Mani, Navyatha Mohan, Neha Akkad, Gautam S D Balasubramania Pandian, Shivraj Savadkar, Ki Buom Lee, Alejandro Torres‐Hernandez, Berk Aykut, B. Diskin, Wei Wang, M. S. Farooq, Arif I Mahmud, G. Werba, Eduardo J Morales, Sarah Lall, Benjamin J. Wadowski, A. Rubin, M. Berman, Rajkishen Narayanan, Mautin Hundeyin, G. Miller   +21 more
semanticscholar   +1 more source

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma.

Gastroenterology, 2017
BACKGROUND & AIMS Induction of nonapoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We investigated necroptosis-based therapies in mouse models of pancreatic ductal adenocarcinoma cancer (PDAC).
Yangchun Xie, Shan Zhu, M. Zhong, Man-gil Yang, Xiaofang Sun, Jinbao Liu, G. Kroemer, M. Lotze, H. Zeh, R. Kang, D. Tang   +10 more
semanticscholar   +1 more source

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm

Human Pathology: Case Reports, 2019
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells is a rare pancreatic tumor of unclear origin. This case reports a 72-year-old male with bloating and indigestion for about six years who was found to have a 5 cm laterally ...
Ahmad Charifa, Zenta Walther, Ronald R. Salem, Dhanpat Jain   +3 more
doaj  

CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway

OncoTargets and Therapy, 2017
Circular RNAs (circRNAs) are a novel class of noncoding RNAs that play an important role in cancer. However, the mechanisms by which circRNAs regulate gene expression in pancreatic ductal adenocarcinoma (PDAC) remain unclear.
Gen-wen Chen, Yanting Shi, Yu Zhang, Jianyong Sun   +3 more
semanticscholar   +1 more source

Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage. [PDF]

PLoS ONE, 2011
Targeting of oncogenic Kras to the pancreatic Nestin-expressing embryonic progenitor cells and subsequently to the adult acinar compartment and Nestin-expressing cells is sufficient for the development of low grade pancreatic intraepithelial neoplasia ...
Catherine Carrière, Alison L Young, Jason R Gunn, Daniel S Longnecker, Murray Korc   +4 more
doaj   +1 more source

IFNγ and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma.

Cancer Discovery, 2016
UNLABELLED Dense fibrosis and a robust macrophage infiltrate are key therapeutic barriers in pancreatic ductal adenocarcinoma (PDAC). CD40 activation can circumvent these barriers by inducing macrophages, originating from peripheral blood monocytes, to ...
Kristen B. Long, W. Gladney, Graham M. Tooker, Kathleen Graham, J. Fraietta, G. Beatty   +5 more
semanticscholar   +1 more source

An indolent pancreatic ductal adenocarcinoma with psammoma bodies and a coincidental neuroendocrine tumor

Human Pathology: Case Reports, 2019
Pancreatic ductal adenocarcinoma is a very aggressive neoplasm with a low survival rate, comprising the majority of pancreatic malignancies. Psammoma bodies have rarely been reported in pancreatic ductal adenocarcinoma, and their clinicopathologic ...
Hongxing Gui, Christopher P. Julien, Suehyb G. Alkhatib, Michael A. Husson   +3 more
doaj  

Pancreatic Duct Stricture That Rapidly Progressed to Pancreatic Ductal Adenocarcinoma and Formed a Mass within 3 Months: A Case Report

Case Reports in Gastroenterology, 2018
The natural growth rate of pancreatic carcinoma in situ with pancreatic duct stricture remains unclear. Herein, we present a case with pancreatic duct stricture that rapidly grew to form a mass lesion within 3 months.
Shin Kato, Kenji Chinen, Susumu Shinoura, Fumihito Kunishima   +3 more
doaj   +1 more source