Results 61 to 70 of about 92,469 (306)

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Fine needle aspiration of pancreatic lesions focusing on secondary tumors with emphasis of metastatic breast cancer: A clinicopathological study with follow‐up

Cancer Medicine, 2023
Background The data on metastatic tumors to the pancreas diagnosed by fine needle aspiration (FNA) biopsy is limited. We report our experience of FNA of primary and secondary pancreatic tumors emphasizing metastatic breast cancer in the pancreas.
Maria Yanqing Chen, Neda Zarrin‐Khameh, Ya Xu   +2 more
doaj   +1 more source

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]

, 2019
York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Diffusion-weighted MR imaging of pancreatic cancer: A comparison of mono-exponential, bi-exponential and non-Gaussian kurtosis models

European Journal of Radiology Open, 2016
Objectives: To compare two Gaussian diffusion-weighted MRI (DWI) models including mono-exponential and bi-exponential, with the non-Gaussian kurtosis model in patients with pancreatic ductal adenocarcinoma.
Nikolaos Kartalis, Georgios C. Manikis, Louiza Loizou, Nils Albiin, Frank G. Zöllner, Marco Del Chiaro, Kostas Marias, Nikolaos Papanikolaou   +7 more
doaj   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target

Medical Sciences Forum, 2023
Integral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes ...
Ahmad Taha Khalaf, Yuanyuan Wei, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Zahraa Oglah   +4 more
doaj   +1 more source

Modified Appleby Procedure with Arterial Reconstruction for Locally Advanced Pancreatic Adenocarcinoma: A Literature Review and Report of Three Unusual Cases. [PDF]

, 2016
BACKGROUND: Pancreatic body and tail ductal adenocarcinomas are often diagnosed with local vascular invasion of the celiac axis (CA) and its various branches. With such involvement, these tumors have traditionally been considered unresectable.
Lamb, Kathleen M., Latona, Jessica A., Maley, Warren R., Pucci, Michael J., Yeo, Charles J.   +4 more
core   +1 more source

Ovarian Metastasis from Pancreatic Ductal Carcinoma

Revista Española de Enfermedades Digestivas
A clinical case is presented about a rare presentation of pancreatic cancer. Firstly, pancreatic cancer rarely metastasizes to the ovary, and when it does, it usually presents in the form of peritoneal carcinomatosis and bilateral involvement. However, the initial radiological diagnosis was primary pancreatic carcinoma with a synchronous primary ...
Cobarro JE, Ramia Ángel JM, Carbonell Morote S, Marcos Sanmartín J, Alcázar-López CF, Villodre Tudela C, Melgar Requena P, García Vega C   +7 more
openaire   +3 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source