Results 71 to 80 of about 63,783 (265)
Case Reports in Gastroenterology, 2018 The natural growth rate of pancreatic carcinoma in situ with pancreatic duct stricture remains unclear. Herein, we present a case with pancreatic duct stricture that rapidly grew to form a mass lesion within 3 months.
Shin Kato +3 more
doaj +1 more source
Advanced Science, EarlyView.A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong +13 more
wiley +1 more source
Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage. [PDF]
PLoS ONE, 2011 Targeting of oncogenic Kras to the pancreatic Nestin-expressing embryonic progenitor cells and subsequently to the adult acinar compartment and Nestin-expressing cells is sufficient for the development of low grade pancreatic intraepithelial neoplasia ...
Catherine Carrière +4 more
doaj +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Patologìâ, 2016 The aim of this work was to determine the levels of mRNA expression of CDK1 and ki67 in pancreatic ductal adenocarcinoma. Materials and methods. The study was conducted on 20 samples of pancreatic tumor tissue taken at pathomorphological examination ...
A. V. Evseyev, A. M. Kamyshnyi
doaj +1 more source
Factors predicting recurrence after resection of pancreatic ductal carcinoma
Suizo, 2005 Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence.A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopathologic factors were evaluated for tumor recurrences by
Shibata, Kohei +5 more
openaire +3 more sources
Targeting claudin‐4 enhances chemosensitivity of pancreatic ductal carcinomas [PDF]
Cancer Medicine, 2019 AbstractClaudin (CLDN) family comprises of protein that form a tight junction, and is involved in regulating polarity and differentiation of cells. Here, we aimed to investigate the effects of inhibiting CLDN4 in pancreatic ductal carcinomas (PDC).
Takamitsu Sasaki +12 more
openaire +3 more sources
Advanced Science, EarlyView.This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu +10 more
wiley +1 more source
Patologìâ, 2015 Differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis with severe fibrosis of the stroma is often complicated by the fact that the rich desmoplastic tumor stroma imitates diffuse foci of fibrosis in pancreatitis. Aim.
V. A. Tumanskiy +2 more
doaj +1 more source
Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment
Advanced Science, EarlyView.This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo +15 more
wiley +1 more source