Results 81 to 90 of about 64,621 (307)
Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Classical monocytes from patients with pancreatic ductal adenocarcinoma exhibit a significantly altered transcriptome profile compared with healthy volunteers [PDF]
, 2014 The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorPancreatic Ductal Adenocarcinoma (PDAC) affects approximately 8000 people every ...
Cook, Jenny Anne
core
Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves [PDF]
, 2013 C/EBPδ is a tumour suppressor transcription factor that induces gene expression involved in suppressing cell migration. Here we investigate whether C/EBPδ-dependent gene expression also affects cell responses to nanometric topology.
Yarwood, Stephen J; id_orcid +6 more
core +1 more source
Case Reports in Gastroenterology, 2018 The natural growth rate of pancreatic carcinoma in situ with pancreatic duct stricture remains unclear. Herein, we present a case with pancreatic duct stricture that rapidly grew to form a mass lesion within 3 months.
Shin Kato +3 more
doaj +1 more source
Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage. [PDF]
PLoS ONE, 2011 Targeting of oncogenic Kras to the pancreatic Nestin-expressing embryonic progenitor cells and subsequently to the adult acinar compartment and Nestin-expressing cells is sufficient for the development of low grade pancreatic intraepithelial neoplasia ...
Catherine Carrière +4 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
Synchronous Pancreas Adenocarcinoma and Breast Infiltrative Ductal Carcinoma [PDF]
, 2014 The association between pancreas adenocarcinoma and breast infitrative ductal carcinoma is extremly rare. A 55-year-old woman was diagnosed as having a pancreatic adenocarcinoma. The patient underwent a Whipple operation.
Simsek, Gurcan +3 more
core +1 more source
Pancreatic Adenosquamous Carcinoma: A Rare Pathological Subtype of Pancreatic Cancer
, 2022 Pancreatic adenosquamous carcinoma (PASC) is a rare pathological subtype of pancreatic cancer (PC), with a worse prognosis than pancreatic ductal adenocarcinoma (PDAC).
Zhang, Zhiwei +7 more
core +1 more source
Patologìâ, 2016 The aim of this work was to determine the levels of mRNA expression of CDK1 and ki67 in pancreatic ductal adenocarcinoma. Materials and methods. The study was conducted on 20 samples of pancreatic tumor tissue taken at pathomorphological examination ...
A. V. Evseyev, A. M. Kamyshnyi
doaj +1 more source