Results 51 to 60 of about 64,621 (307)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Anaplastic Carcinoma of the Pancreas: Clinical and Morphological Characteristics

Case Reports in Gastroenterology, 2020
Anaplastic pancreatic carcinoma is a very rare histological subtype of pancreatic cancer, which is characterized by a more aggressive course than for conventional ductal adenocarcinoma.
Valery I. Podzolkov, Anna E. Pokrovskaya, Tatyana S. Vargina, Andrey B. Ponomarev, Yevgenia A. Kogan, Julia V. Lerner   +5 more
doaj   +1 more source

Diagnosing primary pancreatic acinar cell carcinoma – Clinical correlation of radiological/molecular imaging, histopathologic features and whole genome/transcriptome profiling, and review of the literature

Current Problems in Cancer: Case Reports, 2023
Pancreatic acinar cell carcinoma (ACC) is a rare pancreatic neoplasm, often eluding clinicians because of the lack of diagnosis awareness and expert knowledge regarding clinical, radiological and pathological characteristics of ACC.
Kevin Tran, Owen W.J. Prall, Catherine Mitchell, Angela Chou, Anthony J. Gill, Sean M Grimmond, Grace Kong, Gareth Kiernan, Cristina Torche, Lara Lipton, Benjamin Thomson, HS Ko   +11 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer

, 2013
PMCID: PMC3553106This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Stipo Jurcevic (276415), Bhakta Vipul, Bronner, Mary, Harada, Tomohiko, Barry Sayka, Bronner, M, Mary Bronner (276416), Lattimore Sam, Lemoine Nicholas R., Tomohiko Harada, Teresa A Brentnall, Crnogorac-Jurcevic, Tatjana, Claude Chelala, Brentnall, TA, Mary Bronner, Sam Lattimore (276414), Lattimore, Sam, Tatjana Crnogorac-Jurcevic (57627), Brentnall, Teresa A, Bhakta, V, Crnogorac-Jurcevic, T, Bronner Mary, Teresa A. Brentnall (186815), Chelala, C, Nicholas R. Lemoine (276417), Jurcevic, Stipo, Barry, Sayka, Brentnall Teresa A., Sam Lattimore, Crnogorac-Jurcevic Tatjana, Lemoine, Nicholas R, Lemoine, NR, Lattimore, S, Jurcevic Stipo, Nicholas R Lemoine, Sayka Barry, Tomohiko Harada (276412), Chelala Claude, Harada, T, Stipo Jurcevic, Barry, S, Vipul Bhakta (276413), Chelala, Claude, Jurcevic, S, Bhakta, Vipul, Vipul Bhakta, Sayka Barry (57623), Tatjana Crnogorac-Jurcevic, Claude Chelala (3016), Harada Tomohiko   +49 more
core   +1 more source

High TTK expression drives primary cilia deficiency in ductal carcinomas: An integrated analysis based on TCGA/GTEx data

生物医学转化
Objective To investigate the mechanism underlying primary cilia loss in ductal carcinomas (breast, pancreatic, and cholangiocarcinoma). Methods Transcriptomic data from ductal carcinomas (breast ductal carcinoma, pancreatic ductal adenocarcinoma ...
Li Zhengyang, Yu Hongwei, Zhao Huiming, Pan Feifei, Liu Haotian, Wu Lele, Shi Wengui, Jiao Zuoyi   +7 more
doaj   +1 more source

Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature

World Journal of Surgical Oncology, 2017
Background Simultaneous occurrence of exocrine and neuroendocrine tumors of the pancreas is very infrequent. We report a patient with an endocrine tumor in the pancreatic-duodenal area and extensive exocrine carcinoma involving the whole pancreas.
Simone Serafini, Gianfranco Da Dalt, Gioia Pozza, Stella Blandamura, Michele Valmasoni, Stefano Merigliano, Cosimo Sperti   +6 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source