Results 191 to 200 of about 510,244 (303)

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Metastatic Renal Cell Carcinoma (RCC) [PDF]

, 1991
A. V. Bono, C. Stief, D. E. Johnson, D. G. Skinner, D. H. Garfield, D. J. Fairlamb, D. W. McNichols, E. Allhoff, G. L. Rohdenburg, G. T. Hultquist, H. C. Bumpus Jr., H. E. Stephenson Jr., H. J. G. Bloom, H. J. G. Bloom, H. J. G. Bloom, H. Takatera, I. Satake, J. B. Kernion De, J. B. Kernion De, J. C. Donaldson, J. E. Montie, K. Goldenberg, L. R. Kavoussi, M. M. Mims, R. C. Klugo, R. G. Middleton, R. M. Snow, R. Schlick, S. E. Katz, S. Liedke, S. Z. Freed, T. C. Everson, U. Jonas, W. de Riese, Z. Wajsman   +34 more
core   +1 more source

Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis

Advanced Science, EarlyView.
SeZM NPs selectively target M2b macrophages through mannose–MRC1 (CD206) recognition, enhance GPX1 biosynthesis, and suppress mitochondrial ROS generation, oxidative stress, and JAK–STAT signaling. This dual regulation reduces pro‐inflammatory cytokine release, limits immune cell infiltration and fibrosis, and preserves renal function, providing a ...
Haoran Lv, Guanning Huang, Hongyu Li, Hanzhi Liang, Huajing Peng, Kefei Wu, Wenfang Chen, Dandan Zhang, Kexin Ma, Yufei Du, Siweier Luo, Yi Zhou, Haiping Mao, Wei Chen, Tianfeng Chen, Yiming Zhou, Qinghua Liu   +16 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Clinical outcomes of metastatic non-clear cell renal cell carcinoma: a real-world single-centre experience. [PDF]

Ann Med
Wu J, Cao CZ, Cui HL, Chen MX, Gao LN, Zheng S, Zhou AP, Guan YY, Bi XG, Shi HZ, Shou JZ.   +10 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, EarlyView.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source

Recent developments in eosinophilic renal neoplasms: what's new, true and important? [PDF]

Histopathology
Trpkov K, Siadat F, Saleeb R.
europepmc   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Treatments for renal cell carcinoma: NICE Pilot Treatment Pathways Appraisal.

Health Technol Assess
Lee D, Muthukumar M, Lovell A, Farmer C, Burns D, Matthews J, Coelho H, O'Toole B, Trigg LA, Snowsill TM, Barnish MS, Nikoglou T, Brand A, Ahmad Z, Abdelsabour A, Crathorne L, Robinson S, Wilson EC, Melendez-Torres GJ.   +18 more
europepmc   +1 more source