Results 191 to 200 of about 4,947,478 (390)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Pembrolizumab as Second‐Line Therapy for Advanced Urothelial Carcinoma

New England Journal of Medicine, 2017
J. Bellmunt, R. de Wit, D. Vaughn, Y. Fradet, Jae-Lyun Lee, L. Fong, N. Vogelzang, M. Climent, D. Petrylak, T. Choueiri, A. Necchi, W. Gerritsen, H. Gurney, D. Quinn, S. Culine, C. Sternberg, Yabing Mai, C. Poehlein, R. Perini, D. Bajorin   +19 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Effects of pantothenic acid-deficient diets in patients with carcinomas [PDF]

, 1958
Arthur G. Ship, William E. Schal'Ten, Donald M. Watkin, Marjorie Romine   +3 more
openalex   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

STUDIES ON THE EFFECTS OF ACTINOMYCETES PRODUCTS ON THE CULTURE OF HUMAN CARCINOMA CELLS (STRAIN HELA) I. THE EFFECT OF KNOWN ANTIBIOTICS HAVING NO OR SLIGHT TUMOR-INHIBITORY ACTIVITY ON HELA CELLS

, 1957
Kazuo Nitta
openalex   +2 more sources

A case of columnar‐celled carcinoma of the stomach showing squamous‐celled metaplasia [PDF]

, 1905
Humphry Rolleston, R. Salusbury Trevor
openalex   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.

New England Journal of Medicine, 2016
Robert L Ferris, G. Blumenschein, J. Fayette, J. Guigay, A. Colevas, L. Licitra, K. Harrington, S. Kasper, E. Vokes, C. Even, F. Worden, Nabil F. Saba, L. I. Docampo, R. Haddad, T. Rordorf, N. Kiyota, M. Tahara, M. Monga, M. Lynch, W. Geese, J. Kopit, James W. Shaw, Maura L Gillison   +22 more
semanticscholar   +2 more sources

Two million volt irradiation therapy for inoperable carcinoma of the lung [PDF]

, 1955
Ruth Guttmann
openalex   +1 more source