Results 31 to 40 of about 644 (187)

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Tipos histológicos de cáncer de mama y factores de riesgo asociados con su desarrollo en pacientes que consultaron dos hospitales de Cali

Revistas Argentina de Medicina
Introducción. El cáncer de mama representa una carga significativa para los sistemas de salud en todo el mundo. El objetivo de este estudio fue establecer la prevalencia de los tipos histológicos de cáncer de mama y los factores de riesgo asociados en ...
Mónica Chávez Vivas
doaj   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Histología e inmunohistoquímica del cáncer de mama invasivo en la provincia de Pinar del Río

Revista de Ciencias Médicas de Pinar del Río, 2018
Introducción: El cáncer de mama es la neoplasia más frecuente en mujeres de varios países. Cuba no escapa de este problema de salud. Objetivo: Caracterizar histológica e inmunohistoquímicamente   el  carcinoma  de mama  invasivo en  Pinar del Río 2013 ...
Maikel Ramirez Valle, Grisel Garcia Montesino, Candelaria Lores Hechevarria, Yamirka Sánchez Azcuy, Carlos Márquez Hernández   +4 more
doaj  

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

Breast Modular Resection Surgery Teaching Model Improves the Effect of Teaching Under Regional Anesthesia for Breast Conserving Surgery and Sentinel Lymph Node Biopsy in Day Surgery

Health Care Science, EarlyView.
This study validates a novel Breast Modular Resection (BMR) teaching model for breast‐conserving surgery under regional anesthesia. The BMR approach significantly improves surgical proficiency, reduces re‐excision rates and pain, and facilitates safe day‐case discharge with superior cosmetic outcomes. ABSTRACT Background Breast‐conserving surgery (BCS)
Ru Yao, Aocheng Wu, Jie Lian, Linjuan Tan, Lu Gao, Bo Pan, Qiang Sun, Yidong Zhou   +7 more
wiley   +1 more source

Harnessing microbial metabolism and nutrition to target the gut–mammary axis for better livestock production and health

iMetaOmics, EarlyView.
The gut–mammary axis integrates intestinal health with mammary function through neural, endocrine, and immune pathways. Nutritional interventions (probiotics, prebiotics, metabolites) improve gut microecology, generating microbial signals that travel via the axis to the mammary gland. There, they relieve inflammation, enhance milk quality and lactation,
Aolong Zhou, Cheng Guo, Mahmoud M. Abdelsattar, Ahmad R. Musa, Mequanint Biks, Abdullahi A. Musa, Shahnaz Rahman, Abera Teshome Aleli, Pei Zhong, Jiawei Zhang, Junwei Cui, Xiyan Kou, Qingyuan Yu, Caijuan Yue, Qin Li, Dan Zhang, Zixuan Peng, Ao Ren, Ziqi Tian, Ziqi Liu, Yaona Zhang, Lili Zhang, Dina Karmallah, Naifeng Zhang, Tao Ma, Yan Tu, Qiyu Diao, Guijie Zhang, Xiaofeng Xu, Yanliang Bi   +29 more
wiley   +1 more source

Post‐Radiation Granuloma Annulare: A Series of Three Cases

JEADV Clinical Practice, EarlyView.
ABSTRACT We report typical cases of biopsy confirmed granuloma annulare occurring on irradiated skin in the context of breast cancer in three women in their seventies. The lesions appeared immediately after start of irradiation in one patient, 4 and 15 months after the end of radiation treatment in the other two. The lesions eventually spread elsewhere
Léa Scheid, Mona Mitcov, Dan Lipsker
wiley   +1 more source

El infiltrado tumoral del carcinoma ductal infiltrante en Holguín, Cuba

Correo Científico Médico, 2018
Introducción:  el carcinoma ductal infiltrante  es  la neoplasia maligna mamaria más frecuente. Entre sus características anatomopatológicas se presenta el grado histológico de malignidad, como su  factor  pronóstico.
Nitza Julia Sanz Pupo, Pedro L. Fernández Sanz, Frank A. Fernández Sanz, Pedro A. Fernández Sarabia   +3 more
doaj   +2 more sources

Hamartoma pulmonar como diagnóstico diferencial de metástase de carcinoma de mama: relato de caso Pulmonary hamartoma as a differential diagnosis of breast cancer metastasis: case report

Jornal Brasileiro de Pneumologia, 2007
Relata-se o caso de uma paciente de 60 anos, em menopausa há 14 anos, com presença de nódulo pulmonar à radiografia de tórax diagnosticado no seguimento pós-operatório por neoplasia de mama.
Vanessa Assis da Silva, Paula Kataguiri, Damila Cristina Trufelli, Leandro Luongo de Matos, João Carlos das Neves-Pereira, José Ribas Milanez de Campos   +5 more
doaj   +1 more source