Results 41 to 50 of about 47,297 (213)

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang   +9 more
wiley   +1 more source

Factores predictivos de invasión en carcinoma ductal in situ diagnosticado por biopsia con aguja de corte

open access: yesCirugía y Cirujanos, 2022
Objetivo: Identificar características clínicas, radiológicas e histopatológicas como factores predictivos de carcinoma mamario microinvasor/invasor en pacientes con Carcinoma Ductal In Situ (CDIS) diagnosticado mediante aguja de corte. Material y métodos:
Felipe Villegas-Carlos   +6 more
doaj   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

open access: yesAdvanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

An atypical presentation of infiltrating ductal carcinoma

open access: yesJournal of Family Medicine and Primary Care, 2016
A 64-year-old African-American female presented with nonbloody nipple discharge. Clinical and cytological examination of the discharge was normal. The mammography suggested pleomorphic calcification in the left breast. A stereotactic biopsy showed ductal
Kunal Kishor Jha, Suresh Kumar Gupta
doaj   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

open access: yesAdvanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu   +11 more
wiley   +1 more source

Carcinoma ductal in situ arising in a fibroadenoma: report of a rare case

open access: yesRevista Médica de Minas Gerais, 2021
Although fibroadenoma is one of the most common lesions of the breast, its correlation with malignant changes is rare. When it occurs, the clinical presentation is similar to typical fibroadenomas, anatomopathological diagnosis is after surgery and ...
Jácome, Anna Carolina Pereira   +4 more
doaj   +1 more source

Lymph Node Metastasis Pattern and Influencing Factors in Esophageal Squamous Cell Carcinoma

open access: yesAGING MEDICINE, EarlyView.
Among 388 patients with esophageal squamous cell carcinoma who underwent curative resection, 144 (37.1%) developed lymph node metastasis. Upper thoracic tumors mainly involved upper mediastinal and upper right paratracheal nodes, whereas lower thoracic tumors more often involved paracardial and abdominal nodes.
Yuheng Wang   +3 more
wiley   +1 more source

Immunohistochemical profile of high-grade ductal carcinoma in situ of the breast

open access: yesClinics, 2013
OBJECTIVE: To determine the frequency of the immunohistochemical profiles of a series of high-grade ductal carcinoma in situ of the breast. METHODS: One hundred and twenty-one cases of high-grade ductal carcinoma in situ, pure or associated with invasive
Amanda Arantes Perez   +4 more
doaj  

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino   +4 more
wiley   +1 more source

Consultoria em patologia cirúrgica mamária: variabilidade interobservador no diagnóstico de lesões proliferativas intraductais atípicas Consultation in breast surgical pathology: interobserver diagnostic variability of atypical intraductal proliferative lesions

open access: yesRevista Brasileira de Ginecologia e Obstetrícia, 2013
OBJETIVO: Avaliar a concordância nos diagnósticos histopatológicos de lesões mamárias proliferativas intraductais entre patologistas gerais e especialistas em patologia mamária.
Amanda Arantes Perez   +3 more
doaj  

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