Results 81 to 90 of about 4,738,170 (353)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Pilot Study: Heart Rate and Heart Rate Variability Indices in Mules Evaluated by 24-Hour Electrocardiogram

Animals
Mules and donkeys are the 5th largest equine population in the U.S., yet basic information such as heart rate and arrhythmia prevalence in mules has not been described.
Lauren T. Maas, Jessica M. Morgan, Jordan Case, David D. Chell, Amy K. McLean   +4 more
doaj   +1 more source

Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study

Indian Journal of Radiology and Imaging, 2019
Background: Cardiac iron deposition in transfusion-dependent thalassemia patients is patchy in distribution. Purpose: The purpose of this study is to assess the correlation between T2* matrices of membranous interventricular septum (MIVS) and T2* values ...
Ishan Kumar, Priyanka Aggarwal, Vineeta Gupta, Ashish Verma, Suwen Kumar, Ram C Shukla   +5 more
doaj   +1 more source

The effect of illegal drug screening results and chronic drug use on perioperative complications in trauma

Journal of Emergencies, Trauma and Shock, 2020
Context: Illegal drug use and need for surgery are common in trauma. This allows examination of the effects of perioperative drug use. Aim: The aim was to study the effects of illegal drug use on perioperative complications in trauma. Setting and Design:
John T Culhane, Carl A Freeman
doaj   +1 more source

Metabolically exaggerated cardiac reactions to acute psychological stress revisited [PDF]

, 2009
The reactivity hypothesis postulates that large magnitude cardiovascular reactions to psychological stress contribute to the development of pathology. A key but little tested assumption is that such reactions are metabolically exaggerated.
Allen, Barnett, Blix, Brener, Brosschot, Carroll, Carroll, Carroll, Carroll, Carroll, Cybulski, Cybulski, de Boer, Gronwall, Hastrup, Kamarck, Kubicek, Langer, Light, Lovallo, Lynch, Markovitz, Obrist, Ring, Ring, Schmidt, Schuler, Schwartz, Sherwood, Sherwood, Sims, Steptoe, Stoney, Stromme, Treiber, Turner, Veldhuijzen van Zanten, Waldstein, Willemsen   +38 more
core   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Cell augmentation strategies for cardiac stem cell therapies

Stem Cells Translational Medicine, 2021
Myocardial infarction (MI) has been the primary cause of death in developed countries, resulting in a major psychological and financial burden for society. Current treatments for acute MI are directed toward rapid restoration of perfusion to limit damage
Raquel Cruz‐Samperio, Millie Jordan, Adam Perriman   +2 more
doaj   +1 more source

Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel [PDF]

, 2014
Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5.
Beltran-Alvarez, Pedro, Brugada, Ramon, Díaz-Hernández, Rubí, Feixas, Ferran, Osuna, Sílvia, Pagans, Sara   +5 more
core   +2 more sources