Results 111 to 120 of about 41,114 (313)

Early genetic screening and cardiac intervention in patients with cardiomyopathies in a multidisciplinary clinic

ESC Heart Failure, Volume 12, Issue 3, Page 1942-1955, June 2025.
Abstract Aims Patients with cardiomyopathies are a heterogeneous group of patients who experience high morbidity and mortality. Early cardiac assessment and intervention with access to genetic counselling in a multidisciplinary Cardiomyopathy Clinic may improve outcomes and prevent progression to advanced heart failure.
Chandu Sadasivan, Luke R. Gagnon, Deepan Hazra, Kaiming Wang, Erik Youngson, Jissy Thomas, Anita Y.M. Chan, D. Ian Paterson, Finlay A. McAlister, Tara Dzwiniel, Wayne Tymchak, Susan Christian, Gavin Y. Oudit   +12 more
wiley   +1 more source

Multi-Imaging Characterization of Cardiac Phenotype in Different Types of Amyloidosis [PDF]

, 2022
BACKGROUND: Bone scintigraphy is extremely valuable when assessing patients with suspected cardiac amyloidosis (CA), but the clinical significance and associated phenotype of different degrees of cardiac uptake across different types is yet to be defined.
Brown, James, Chacko, Liza, Fontana, Marianna, Gillmore, Julian D, Hawkins, Philip N, Ioannou, Adam, Kellman, Peter, Knight, Daniel, Kotecha, Tushar, Lachmann, Helen, Manisty, Charlotte, Martinez-Naharro, Ana, Moon, James, Patel, Rishi K, Porcari, Aldostefano, Razvi, Yousuf, Venneri, Lucia, Wechelakar, Ashutosh, Whelan, Carol, Wisniowski, Brendan   +19 more
core  

State of precision medicine for heart failure with preserved ejection fraction in a new therapeutic age

ESC Heart Failure, Volume 12, Issue 3, Page 1544-1557, June 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is defined by heart failure (HF) with a left ventricular ejection fraction (LVEF) of at least 50%. HFpEF has a complex and heterogeneous pathophysiology with multiple co‐morbidities contributing to its presentation. Establishing the diagnosis of HFpEF can be challenging.
Roy Rasalam, Andrew Sindone, Gary Deed, Ralph G. Audehm, John J. Atherton   +4 more
wiley   +1 more source

Cardiac Structural and Functional Consequences of Amyloid Deposition by Cardiac Magnetic Resonance and Echocardiography and Their Prognostic Roles [PDF]

, 2019
OBJECTIVES: This cross-sectional study aimed to describe the functional and structural cardiac abnormalities that occur across a spectrum of cardiac amyloidosis burden and to identify the strongest cardiac functional and structural prognostic predictors ...
Abdel-Gadir, A, Barcella, W, Bulluck, H, Fontana, M, Francis, R, Gillmore, JD, Hawkins, PN, Knight, DS, Kotecha, T, Lachmann, HJ, Martinez-Naharro, A, Moon, JC, Muthurangu, V, Quarta, CC, Rezk, T, Steeden, JA, Treibel, TA, Wechalekar, AD, Whelan, CJ, Zumbo, G   +19 more
core  

Treatment patterns, outcomes and healthcare resource utilization of obstructive hypertrophic cardiomyopathy in England

ESC Heart Failure, Volume 12, Issue 3, Page 2034-2046, June 2025.
Abstract Aims Describe patient characteristics, treatment patterns, clinical outcomes, healthcare resource utilization (HCRU) and medical costs associated with patients who were diagnosed with obstructive hypertrophic cardiomyopathy (HCM) in clinical practice in England.
Faizel Osman, Carla L. Zema, Michael Hurst, Belinda Sandler, Florence Brellier, Ovie Utuama, Oksana Kirichek, John Houghton, Teresa Lemmer, Maite Tome Esteban   +9 more
wiley   +1 more source

Non-native beta-sheet formation: insights into protein amyloidosis [PDF]

arXiv, 2002
Protein amyloidosis is a cytopathological process characterized by the formation of highly beta-sheet-rich fibrils. How this process occurs and how to prevent/treat the associated diseases are not completely understood. Here, we carry out a theoretical investigation of sequence-independent beta-sheet formation, based on recent findings regarding the ...
arxiv  

Sudden death in lambda light chain AL cardiac amyloidosis: a review of literature and update for clinicians and pathologists [PDF]

, 2020
Light chain (AL) amyloidosis is the most common type of systemic amyloidosis, affecting around 10 people per million per year. In Europe, approximately 5000 new diagnosis per year are reported.
Baldari, Benedetta, D'Errico, Stefano, Fineschi, Vittorio, Frati, Paola, Maiese, Aniello, Mazzanti, Andrea   +5 more
core  

Prevalence and prognostic value of different iron deficiency definitions in light chain cardiac amyloidosis patients

ESC Heart Failure, Volume 12, Issue 3, Page 2134-2147, June 2025.
Non‐scaled Venn diagram of iron deficiency (ID) according to various definitions and associated outcomes. The prevalence of iron deficiency was high, irrespective of the definition applied. ID defined by TSAT <20% or serum iron <13 μmol/L, rather than the guideline definition, was associated with worse outcomes.
Xinqing Li, Anran Xin, Yan Huang, Qiong Zhou, Jinxi Wang, Ping Zhou, Stefan D. Anker, Yuhui Zhang   +7 more
wiley   +1 more source

Cardiac Amyloidosis Versus Other Restrictive Cardiomyopathies: A Retrospective Analysis of Cardiovascular Outcomes and Arrhythmic Burden

Clinical Medicine Insights: Cardiology
Background: The arrhythmic burden and cardiovascular risks of cardiac amyloidosis compared with other types of restrictive cardiomyopathies (RCM), such as hemochromatosis and cardiac sarcoid, have not been well characterized in the literature.
Andrew Sagalov, Waqas Ullah, Yevgeniy Brailovsky, Michael Buhnerkempe, Steve Scaife, Abhishek Kulkarni, Mohamed Labedi, Shruti Hegde   +7 more
doaj   +1 more source

Relating the spectrum of cardiac signals to the spatiotemporal dynamics of cardiac sources [PDF]

arXiv, 2013
An increasing number of studies use the spectrum of cardiac signals for analyzing the spatiotemporal dynamics of complex cardiac arrhythmias. However, the relationship between the spectrum of cardiac signals and the spatiotemporal dynamics of the underlying cardiac sources remains to date unclear.
arxiv