Results 71 to 80 of about 194,967 (316)

A narrative review of inherited arrhythmogenic syndromes in young population: role of genetic diagnosis in exercise recommendations

BMJ Open Sport & Exercise Medicine
Sudden cardiac death is a rare but socially devastating event, especially if occurs in young people. Usually, this unexpected lethal event occurs during or just after exercise. One of the leading causes of sudden cardiac death is inherited arrhythmogenic
Elena Arbelo, Gonzalo Grazioli, Carles Díez-López, Oscar Campuzano, Georgia Sarquella-Brugada, Sergi Cesar, Estefanía Martínez-Barrios, Rocío Toro, José Cruzalegui, Andrea Greco, Nuria Díez-Escuté, Patricia Cerralbo, Fredy Chipa, Norma Balderrábano   +13 more
doaj   +1 more source

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6

, 2012
Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca2+-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating.
Mano Sitsapesan (182017), Tsaneva-Atanasova, Krasimira, Samantha J Pitt, Pitt Samantha J., Zaccai, N, Krasimira Tsaneva-Atanasova (144624), Sitsapesan, Rebecca, Tsaneva-Atanasova, KT, Pitt, SJ, Stephen O'Neill (182027), Zaccai Nathan R., Tsaneva-Atanasova Krasimira, Sitsapesan Rebecca, O'Neill Stephen, Galfre, Elena, Pitt, Samantha Jane, Nathan R. Zaccai (182021), Venturi Elisa, Sitsapesan, Mano, Mano Sitsapesan, Galfré Elena, Rebecca Sitsapesan (182033), Sitsapesan Mano, Rebecca Sitsapesan, Venturi, E, Galfré, E, Samantha J. Pitt (182004), Tsaneva-Atanasova, K, Stephen O'Neill, Elisa Venturi, Elena Galfré, Elena Galfré (182000), Elisa Venturi (182009), Zaccai, NR, O'Neill, Stephen, Nathan R Zaccai, Sitsapesan, R, O'Neill, S, Krasimira Tsaneva-Atanasova, Venturi, Elisa, Zaccai, Nathan R, Sitsapesan, M   +41 more
core   +2 more sources

Investigation on Sudden Unexpected Death in the Young (SUDY) in Europe: results of the European Heart Rhythm Association Survey.

, 2022
The aims of this centre-based survey, promoted and disseminated by the European Heart Rhythm Association (EHRA) was to investigate the current practice for the investigation of Sudden Unexplained Death in the Young (SUDY) amongst European countries.
Frampton, Katie, Scrocco, Chiara, Rudaka, I, Schulze-Bahr, E, Crotti, L, Remme, Carol A, Remme, CA, Wilde, Arthur A. M., Boveda, S, Kosiuk, J, de Asmundis, Carlo, Wilde, AAM, Iliodromitis, KE, Crotti, Lia, Kosiuk, Jedrzej, Marijon, Eloi, Remme, Carol A., Jubele, K, Schulze-Bahr, Eric, Boveda, Serge, Behr, Elijah R., Wilde, Arthur A M, Iliodromitis, Konstantinos E., Jubele, Kristine, Wilde, Arthur A.M., de Asmundis, C, Conte, G, Brugada, GS, Hofman, Nynke, Tfelt-Hansen, Jacob, Rudaka, Irina, Behr, Elijah R, Tfelt-Hansen, J, Iliodromitis, Konstantinos E, Hofman, N, Conte, Giulio, Marijon, E, Frampton, K, Behr, ER, Scrocco, C, Brugada, Georgia Sarquella   +40 more
core   +2 more sources

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Actionable Variants of Unknown Significance in Inherited Arrhythmogenic Syndromes: A Further Step Forward in Genetic Diagnosis

Biomedicines
Background/Objectives: Inherited arrhythmogenic syndromes comprise a heterogenic group of genetic entities that lead to malignant arrhythmias and sudden cardiac death.
Estefanía Martínez-Barrios, Andrea Greco, José Cruzalegui, Sergi Cesar, Nuria Díez-Escuté, Patricia Cerralbo, Fredy Chipa, Irene Zschaeck, Miguel Fogaça-da-Mata, Carles Díez-López, Elena Arbelo, Simone Grassi, Antonio Oliva, Rocío Toro, Georgia Sarquella-Brugada, Oscar Campuzano   +15 more
doaj   +1 more source

Modern pharmacological approach to arrhythmias in the 21st century

, 2023
Recent improvements in diagnosis techniques, increasing knowledge of changes in cardiac metabolism and the impact of electrolyte disturbance on the formation of arrhythmias, and the understandings of the pharmacological properties of both new and old ...
Katan, Karin
core  

Integrated Ultrasonic Platform for Bioelectronic Control through Biological Barriers Based on Metasurface

Advanced Science, EarlyView.
A metasurface‐enabled ultrasonic platform achieves precise multi‐focal control through biological barriers, real‐time physiology‐driven modulation, and simultaneous wireless power and data transmission. By unifying wavefront engineering, closed‐loop feedback, and acoustic communication, this work establishes key enabling technologies toward scalable ...
Chuanxin Zhang, Hanjie Xiao, Xue Jiang, Dean Ta   +3 more
wiley   +1 more source

Handgrip strength test for the diagnosis of long QT syndrome

Российский кардиологический журнал
Long QT syndrome (LQTS) assessment is based on the QT/ÖRR equation (the so-called Bazett's formula) and calculating the corrected QT (QTc). However, this formula reliably estimates the QT interval in the heart rate range (HR) of 60-90 bpm, which makes it
V. N. Komoliatova, L. M. Makarov, A. G. Akopyan, A. N. Komarov, N. V. Aksenova, D. A. Besportochny   +5 more
doaj   +1 more source

Worldwide survey of COVID-19–associated arrhythmias

, 2021
Background: Coronavirus disease 2019 (COVID-19) has led to over 1 million deaths worldwide and has been associated with cardiac complications including cardiac arrhythmias. The incidence and pathophysiology of these manifestations remain elusive. In this
Angelo Biviano, Felipe Fernández-Vázquez, Pietro Enea Lazzerini, Brenno Rizerio, Daniele Fabbri, Giuseppe Boriani, Ellie J. Coromilas, Seongwook Han, Ilhwan Yeo, Eduardo Zatarain, Stefan Osswald, Wee Kooi Cheah, Carlos Minguito-Carazo, Jose A. Joglar, Yi Li, Shant Ayanian, Cynthia Tracy, Pier Leopoldo Capecchi, Marco Zardini, Lia Crotti, Julio Echarte-Morales, Federico Migliore, Paola Ferrari, Andrew Aboyme, Tomás Benito-González, Nicolas Schaerli, James Coromilas, Carlos A. Rivera-Santiago, Jongmin Hwang, Alberto Cipriani, Gary Tse, Serena Bricoli, Angelo Auricchio, Stephanie Kochav, Isaac Goldenthal, Ghada W. Mikhail, Rosario Bonura, Maurício Pimentel, Keith Sai Kit Leung, Federico Franchi, Leandro Zimerman, Giulio Conte, Chia Siang Kow, Saud Khawaja, Giovanni Malanchini, Reza Mollazadeh, Shashank Jain, Felipe Atienza, Prapa Kanagaratnam, Ludhmila Abrahão Hajjar, Joseph Akar, Elaine Y. Wan, Gianfranco Parati, Masoud Eslami, Anna G. Rosenblatt, Joon-Hyuk Kim, Connor Galen O’Brien, Melissa Moey, Vahideh Laleh far, Paul J. Wang, Anna Vittoria Mattioli, Luciana Sacilotto, Antonio Dello Russo, Avinainder Singh, Aditi Naniwadekar, Amato Santoro, Mauricio Scanavacca, Kyoko Soejima, Raphael Twerenbold, Hasan Garan, Seth Goldbarg, Milton E. Guevara-Valdivia, Paolo De Filippo, Filippo Donato, Paolo Compagnucci, Michela Casella, Fatima Rodriguez   +75 more
core   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source