Results 61 to 70 of about 194,967 (316)

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Prevalence of arterial hypertension in young elite athletes with a hypertensive type of response to physical activity

Спортивная медицина: наука и практика
Aim of the study: to assess the prevalence of arterial hypertension in athletes with high BP values during an exercise test.Methods: out of 2313 athletes 14–18 (15.5 ± 1.4) years old, according to the results of VEM, 128 (6 %; 60 m) people with high ...
V. N. Komoliatova, D. A. Besportochnii, L. M. Makarov, I. I. Kiseleva, N. V. Aksenova   +4 more
doaj   +1 more source

Proarrhythmia associated with antiarrhythmic drugs: a comprehensive disproportionality analysis of the FDA adverse event reporting system

Frontiers in Pharmacology, 2023
Objective: This study aimed to identify the different associations between antiarrhythmic drugs (AADs) and arrhythmias, and to determine whether pharmacokinetic drug interactions involving AADs increase the risk of AAD-related arrhythmias compared to ...
Feifei Wang, Bingfeng Zhou, Hongwei Sun, Xinan Wu   +3 more
doaj   +1 more source

Does the revised cardiac risk index predict cardiac complications following elective lung resection? [PDF]

, 2013
Background: Revised Cardiac Risk Index (RCRI) score and Thoracic Revised Cardiac Risk Index (ThRCRI) score were developed to predict the risks of postoperative major cardiac complications in generic surgical population and thoracic surgery respectively.
Pala Rajesh, Naidu, Babu V, Babu Naidu, Marshall, Andrea, Bishay, Ehab, Maninder Kalkat, Ehab Bishay, Kerr, Amy, Richard Steyn, Wotton, Robin, Kalkat, Maninder, Steyn, Richard, Naidu, Babu, Rajesh, Pala B, Amy Kerr, Andrea Marshall, Kalkat, Maninder S, Marshall, A. (Andrea), Rajesh, Pala, Robin Wotton   +19 more
core   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Incident cardiac arrhythmias associated with metabolic dysfunction-associated steatotic liver disease: a nationwide histology cohort study

Cardiovascular Diabetology, 2023
Background Prior studies suggest a link between metabolic dysfunction-associated steatotic liver disease (MASLD) and incident arrhythmias, including atrial fibrillation (AF).
Tracey G. Simon, Fahim Ebrahimi, Bjorn Roelstraete, Hannes Hagström, Johan Sundström, Jonas F. Ludvigsson   +5 more
doaj   +1 more source

Iron Deposition following Chronic Myocardial Infarction as a Substrate for Cardiac Electrical Anomalies: Initial Findings in a Canine Model

, 2013
Purpose: Iron deposition has been shown to occur following myocardial infarction (MI). We investigated whether such focal iron deposition within chronic MI lead to electrical anomalies. Methods: Two groups of dogs (ex-vivo (n = 12) and in-vivo (n = 10))
Cokic Ivan, Stewart Brian, Tang, Richard, Cokic, Ivan, Wang Xunzhang, Allen M Amorn, Thajudeen, Anees, Bennett, Nathan, Richard L Q Tang, Nathan Bennett (459351), Amorn, Allen M., Sotirios A Tsaftaris, Bennett Nathan, Harlev Doron, Thajudeen Anees, Tsaftaris Sotirios A., Chugh, Sumeet S., Brian Stewart, Harlev, Doron, Allen M. Amorn (459348), Sumeet S. Chugh (215629), Tsaftaris, Sotirios A., Shehata Michael, Xunzhang Wang, Rohan Dharmakumar (459355), Chugh Sumeet S., Dharmakumar Rohan, Doron Harlev, Hsin-Jung Yang, Yang, Hsin-Jung, Amorn Allen M., Brian Stewart (459350), Wang, Xunzhang, Avinash Kali, Enzhao Liu, Nathan Bennett, Avinash Kali (459342), Warren M. Jackman (459354), Michael Shehata, Richard L. Q. Tang (459345), Tang Richard L. Q., Hsin-Jung Yang (459344), Michael Shehata (459347), Warren M Jackman, Jackman Warren M., Liu Enzhao, Liu, Enzhao, Sotirios A. Tsaftaris (459353), Ivan Cokic (459341), Rohan Dharmakumar, Stewart, Brian, Sumeet S Chugh, Ivan Cokic, Anees Thajudeen, Enzhao Liu (459349), Yang Hsin-Jung, Dharmakumar, Rohan, Jackman, Warren M., Kali, Avinash, Doron Harlev (459352), Shehata, Michael, Anees Thajudeen (459346), Kali Avinash, Xunzhang Wang (459343)   +63 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

"Re-evaluation of variants of uncertain significance in patients with hereditary arrhythmogenic disorders"

BMC Cardiovascular Disorders
Background Genetic diagnostics support the diagnosis of hereditary arrhythmogenic diseases, but variants of uncertain significance (VUS) complicate matters, emphasising the need for regular reassessment.
Sarah Martin, Tina Jenewein, Christof Geisen, Stefanie Scheiper-Welling, Silke Kauferstein   +4 more
doaj   +1 more source