Results 21 to 30 of about 288,316 (180)

In vivo visualization and molecular targeting of the cardiac conduction system

Journal of Clinical Investigation, 2022
Accidental injury to the cardiac conduction system (CCS), a network of specialized cells embedded within the heart and indistinguishable from the surrounding heart muscle tissue, is a major complication in cardiac surgeries. Here, we addressed this unmet
W. Goodyer, Benjamin M. Beyersdorf, Lauren Duan, N. S. van den Berg, Sruthi Mantri, Francisco X. Galdos, N. Puluca, J. Buikema, Soah Lee, D. Salmi, Elise R. Robinson, Stephan Rogalla, D. Cogan, C. Khosla, E. Rosenthal, Sean M. Wu   +15 more
semanticscholar   +1 more source

Incidence of carditis and predictors of pacemaker implantation in patients hospitalized with Lyme disease

PLoS ONE, 2021
Background Lyme carditis, defined as direct infection of cardiac tissue by Borrelia bacteria, affects up to 10% of patients with Lyme disease. The most frequently reported clinical manifestation of Lyme carditis is cardiac conduction system disease.
Uwajachukwumma A. Uzomah, Guy Rozen, Seyed Mohammadreza Hosseini, Ayman Shaqdan, Pablo A. Ledesma, Xuejing Yu, Pegah Khaloo, Jennifer Galvin, Leon M. Ptaszek, Jeremy N. Ruskin   +9 more
doaj   +2 more sources

First in situ 3D visualization of the human cardiac conduction system and its transformation associated with heart contour and inclination

Scientific Reports, 2021
Current advanced imaging modalities with applied tracing and processing techniques provide excellent visualization of almost all human internal structures in situ; however, the actual 3D internal arrangement of the human cardiac conduction system (CCS ...
T. Kawashima, F. Sato
semanticscholar   +1 more source

Genetic and physiologic dissection of the vertebrate cardiac conduction system. [PDF]

PLoS Biology, 2008
Vertebrate hearts depend on highly specialized cardiomyocytes that form the cardiac conduction system (CCS) to coordinate chamber contraction and drive blood efficiently and unidirectionally throughout the organism.
Neil C Chi, Robin M Shaw, Benno Jungblut, Jan Huisken, Tania Ferrer, Rima Arnaout, Ian Scott, Dimitris Beis, Tong Xiao, Herwig Baier, Lily Y Jan, Martin Tristani-Firouzi, Didier Y R Stainier   +12 more
doaj   +1 more source

Conduction System Pacing for Cardiac Resynchronization Therapy

Journal of Cardiovascular Development and Disease, 2023
Cardiac resynchronization therapy (CRT) via biventricular pacing (BiVP-CRT) is considered a mainstay treatment for symptomatic heart failure patients with reduced ejection fraction and wide QRS. However, up to one-third of patients receiving BiVP-CRT are
Óscar Cano, Javier Navarrete-Navarro, Pablo Jover, Joaquín Osca, Maite Izquierdo, Josep Navarro, Hebert D. Ayala, Luis Martínez-Dolz   +7 more
doaj   +1 more source

PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction

International Journal of Molecular Sciences, 2021
Cardiac development is a complex process that is strictly controlled by various factors, including PcG protein complexes. Several studies have reported the critical role of PRC2 in cardiogenesis. However, little is known about the regulation mechanism of
Xixia Peng, Gang Feng, Yanyong Zhang, Yuhua Sun   +3 more
semanticscholar   +1 more source

Left Bundle Branch Pacing in Transthyretin Cardiac Amyloidosis and Alternating Bundle Branch Block

JACC: Case Reports, 2020
Progressive conduction system disease affects patients with transthyretin cardiac amyloidosis, often requiring permanent pacing as the His-Purkinje system is affected. We present a case of left bundle branch pacing in a patient with transthyretin cardiac
Taha Ahmed, MD, Samra Haroon Lodhi, MBBS, Hassan Lak, MD, Jae Lee, MD, Mazen Hanna, MD, Roy Chung, MD   +5 more
doaj   +1 more source

The evolving state of cardiac resynchronization therapy and conduction system pacing: 25 years of research at EP Europace journal

Europace, 2023
Cardiac resynchronization therapy (CRT) was proposed in the 1990s as a new therapy for patients with heart failure and wide QRS with depressed left ventricular ejection fraction despite optimal medical treatment.
K. Ellenbogen, A. Auricchio, H. Burri, M. Gold, C. Leclercq, F. Leyva, C. Linde, M. Jastrzębski, F. Prinzen, K. Vernooy   +9 more
semanticscholar   +1 more source

Desmin variants: Trigger for cardiac arrhythmias?

Frontiers in Cell and Developmental Biology, 2022
Desmin (DES) is a classical type III intermediate filament protein encoded by the DES gene. Desmin is abundantly expressed in cardiac, skeletal, and smooth muscle cells.
Wei Su, Wei Su, Stan W. van Wijk, Stan W. van Wijk, Bianca J. J. M. Brundel, Bianca J. J. M. Brundel   +5 more
doaj   +1 more source

Development of the Cardiac Conduction System.

Cold Spring Harbor Perspectives in Biology, 2020
The cardiac conduction system initiates and propagates each heartbeat. Specialized conducting cells are a well-conserved phenomenon across vertebrate evolution, although mammalian and avian species harbor specific components unique to organisms with four-
Samadrita Bhattacharyya, N. Munshi
semanticscholar   +1 more source