Results 1 to 10 of about 191,066 (329)

Development and Function of the Cardiac Conduction System in Health and Disease [PDF]

Journal of Cardiovascular Development and Disease, 2017
The generation and propagation of the cardiac impulse is the central function of the cardiac conduction system (CCS). Impulse initiation occurs in nodal tissues that have high levels of automaticity, but slow conduction properties.
David S. Park, Glenn I. Fishman
doaj   +4 more sources

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases. [PDF]

Cardiovascular Research, 2020
AIMS The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge.
Kenshi Hayashi, R. Teramoto, A. Nomura, Y. Asano, M. Beerens, Y. Kurata, Isao Kobayashi, N. Fujino, H. Furusho, K. Sakata, K. Onoue, David Y. Chiang, T. Kiviniemi, E. Buys, P. Sips, Micah L Burch, Yanbin Zhao, Amy E. Kelly, M. Namura, Y. Kita, Taketsugu Tsuchiya, B. Kaku, K. Oe, Yuko Takeda, T. Konno, M. Inoue, T. Fujita, Takeshi Kato, A. Funada, H. Tada, A. Hodatsu, C. Nakanishi, Y. Sakamoto, T. Tsuda, Y. Nagata, Yoshihiro Tanaka, H. Okada, K. Usuda, S. Cui, Yoshihiko Saito, C. Macrae, S. Takashima, M. Yamagishi, M. Kawashiri, M. Takamura   +44 more
semanticscholar   +7 more sources

Conduction System Pacing Versus Conventional Cardiac Resynchronization Therapy in Congenital Heart Disease. [PDF]

JACC: Clinical Electrophysiology, 2022
BACKGROUND Dyssynchrony-associated left ventricular systolic dysfunction is a major contributor to heart failure in congenital heart disease (CHD). Although conventional cardiac resynchronization therapy (CRT) has shown benefit, the comparative efficacy ...
J. Moore, N. D. de Groot, M. O'Connor, Daniel Cortez, Jonathan Su, A. Burrows, K. Shannon, Edward T O'Leary, Maully J. Shah, P. Khairy, J. Atallah, Tom Wong, M. Lloyd, Y. Taverne, A. Dubin, J. Nielsen, Reinder Evertz, R. Czosek, Malini Madhavan, Philip M. Chang, A. Aydın, Ó. Cano   +21 more
semanticscholar   +4 more sources

Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. [PDF]

Journal of Molecular and Cellular Cardiology, 2008
Mutations in the lamin A/C (LMNA) gene, which encodes nuclear membrane proteins, cause a variety of human conditions including dilated cardiomyopathy (DCM) with associated cardiac conduction system disease.
C. Wolf, Libin Wang, R. Alcalai, A. Pizard, P. Burgon, Ferhaan Ahmad, M. Sherwood, D. Branco, H. Wakimoto, G. Fishman, Vincent Y. See, C. Stewart, D. Conner, C. Berul, C. Seidman, J. Seidman   +15 more
semanticscholar   +3 more sources

Rare SCN10A variants associated with cardiac conduction system diseases [PDF]

European Heart Journal, 2020
The genetic bases of cardiac conduction-system disease (CCSD) range from ion channelopathies to mutations in many other genes. Genome-wide association studies have shown common variants in SCN10A influence cardiac conduction.
K. Hayashi, N. Fujino, H. Furusho, S. Usui, K. Sakata, Takeshi Kato, T. Tsuda, S. Niwa, K. Takeuchi, M. Kawashiri, M. Takamura   +10 more
semanticscholar   +2 more sources

Association of atrial tachyarrhythmia, heart block, and right ventricular dysfunction: a case report and review of literature [PDF]

Journal of Medical Case Reports
Background The association of right ventricular dysfunction, atrial tachyarrhythmias, and cardiac conduction system disease is rarely reported in literature. Previous case reports include right ventricular dysfunction associated with sudden cardiac death
Mohamed Muharram, Sherien Samy, Ahmed Shaaban, Ahmed El-Damaty   +3 more
doaj   +2 more sources

Cardiac hypertrophy, accessory pathway, and conduction system disease in an adolescent: the PRKAG2 cardiac syndrome.

Journal of the American College of Cardiology, 2013
We present the case of PRKAG2 cardiac syndrome, a rare autosomal-dominant genetic disease characterized by peculiar clinical and electrophysiological abnormalities. We clearly show through the images the peculiar clinical features that should raise suspicion of a mutant PRKAG2 gene. Indeed, together with an accurate clinical and instrumental evaluation,
E. Fabris, Francesca Brun, A. Porto, Pasquale Losurdo, L. Vitali Serdoz, M. Zecchin, G. M. Severini, L. Mestroni, A. Di Chiara, G. Sinagra   +9 more
semanticscholar   +5 more sources

Novel PRKAG2 Mutation Responsible for the Genetic Syndrome of Ventricular Preexcitation and Conduction System Disease With Childhood Onset and Absence of Cardiac Hypertrophy [PDF]

Circulation, 2001
Background — We recently reported a mutation in the PRKAG2 gene to be responsible for a familial syndrome of ventricular preexcitation, atrial fibrillation, conduction defects, and cardiac hypertrophy. We now report
M. Gollob, J. Seger, Tanya N. Gollob, Terry Tapscott, Oscar Gonzales, L. Bachinski, R. Roberts   +6 more
semanticscholar   +3 more sources

The natural history of symptomatic cardiac conduction-system disease in end-stage renal disease. [PDF]

Nephrology Dialysis Transplantation, 2016
Thomas R. Kambur, M. Das, R. Agarwal
semanticscholar   +3 more sources

Prevalence of cardiac fibrosis and infiltrative cardiomyopathy in patients with advanced conduction system disease

Journal of Arrhythmia
Background Conduction system disease may represent an early manifestation of underlying structural heart disease, including infiltrative disorders.
Jeremy William, Haider Muthana, Joseph Hogarty, Andrew Taylor, James L. Hare, Justin Mariani, Hitesh Patel, Geoff Wong, Dion Stub, David M. Kaye, Sandeep Prabhu, Peter M. Kistler, Aleksandr Voskoboinik   +12 more
doaj   +2 more sources