Results 11 to 20 of about 178,867 (336)

Development and Function of the Cardiac Conduction System in Health and Disease [PDF]

Journal of Cardiovascular Development and Disease, 2017
The generation and propagation of the cardiac impulse is the central function of the cardiac conduction system (CCS). Impulse initiation occurs in nodal tissues that have high levels of automaticity, but slow conduction properties.
David S. Park, Glenn I. Fishman
doaj   +6 more sources

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases [PDF]

Cardiovascular Research, 2020
Aims The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge.
Kenshi Hayashi, Ryota Teramoto, Akihiro Nomura, Yoshihiro Asano, Manu Beerens, Yasutaka Kurata, Isao Kobayashi, Noboru Fujino, Hiroshi Furusho, Kenji Sakata, Kenji Onoue, David Y. Chiang, Tuomas Kiviniemi, Eva Buys, Patrick Sips, Micah L. Burch, Yanbin Zhao, Amy E. Kelly, Masanobu Namura, Yoshihito Kita, Taketsugu Tsuchiya, Bunji Kaku, Kotaro Oe, Yuko Takeda, Tetsuo Konno, Masaru Inoue, Takashi Fujita, Takeshi Kato, Akira Funada, Hayato Tada, Akihiko Hodatsu, Chiaki Nakanishi, Yuichiro Sakamoto, Toyonobu Tsuda, Yoji Nagata, Yoshihiro Tanaka, Hirofumi Okada, Keisuke Usuda, Shi-He Cui, Yoshihiko Saito, Calum A. MacRae, Seiji Takashima, Masakazu Yamagishi, Masa‐aki Kawashiri, Masayuki Takamura   +44 more
core   +9 more sources

Prevalence of cardiac fibrosis and infiltrative cardiomyopathy in patients with advanced conduction system disease [PDF]

Journal of Arrhythmia
Background Conduction system disease may represent an early manifestation of underlying structural heart disease, including infiltrative disorders.
Jeremy William, Haider Muthana, Joseph Hogarty, Andrew Taylor, James L. Hare, Justin Mariani, Hitesh Patel, Geoff Wong, Dion Stub, David M. Kaye, Sandeep Prabhu, Peter M. Kistler, Aleksandr Voskoboinik   +12 more
doaj   +4 more sources

Conduction System Pacing Versus Conventional Cardiac Resynchronization Therapy in Congenital Heart Disease [PDF]

JACC: Clinical Electrophysiology, 2022
Dyssynchrony-associated left ventricular systolic dysfunction is a major contributor to heart failure in congenital heart disease (CHD). Although conventional cardiac resynchronization therapy (CRT) has shown benefit, the comparative efficacy of cardiac conduction system pacing (CSP) is unknown.The purpose of this study was compare the clinical ...
Jeremy P. Moore, Natasja M.S. de Groot, Matthew O’Connor, Daniel Cortez, Jonathan K. Su, Austin Burrows, Kevin Shannon, Edward T. O’Leary, Maully J. Shah, Paul Khairy, Joseph Atallah, Tom Wong, Michael S. Lloyd, Yannick J.H.J. Taverne, Anne M. Dubin, Jens Cosedis Nielsen, Reinder Evertz, Richard J. Czosek, Malini Madhavan, Philip M. Chang, Alper Aydın, Óscar Cano   +21 more
semanticscholar   +6 more sources

Rare SCN10A variants associated with cardiac conduction system diseases [PDF]

European Heart Journal, 2020
Abstract Background The genetic bases of cardiac conduction-system disease (CCSD) range from ion channelopathies to mutations in many other genes. Genome-wide association studies have shown common variants in SCN10A influence cardiac conduction.
Kenshi Hayashi, Noboru Fujino, Hiroshi Furusho, Soichiro Usui, Kenji Sakata, Tamayo Kato, Toshihide Tsuda, Satoru Niwa, Kazuhiko Takeuchi, Masa‐aki Kawashiri, Masayuki Takamura   +10 more
semanticscholar   +3 more sources

Cardiac Hypertrophy, Accessory Pathway, and Conduction System Disease in an Adolescent

Journal of the American College of Cardiology, 2013
We present the case of PRKAG2 cardiac syndrome, a rare autosomal-dominant genetic disease characterized by peculiar clinical and electrophysiological abnormalities. We clearly show through the images the peculiar clinical features that should raise suspicion of a mutant PRKAG2 gene. Indeed, together with an accurate clinical and instrumental evaluation,
Enrico Fabris, Francesca Brun, Andrea Giuseppe Porto, Pasquale Losurdo, Laura Vitali Serdoz, Massimo Zecchin, Giovanni Maria Severini, Luisa Mestroni, Antonio Di Chiara, Gianfranco Sinagra   +9 more
semanticscholar   +7 more sources

Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease [PDF]

Journal of Molecular and Cellular Cardiology, 2007
Mutations in the lamin A/C (LMNA) gene, which encodes nuclear membrane proteins, cause a variety of human conditions including dilated cardiomyopathy (DCM) with associated cardiac conduction system disease. To investigate mechanisms responsible for electrophysiologic and myocardial phenotypes caused by dominant human LMNA mutations, we performed ...
Cordula M. Wolf, Libin Wang, Ronny Alcalai, Anne Pizard, Patrick G. Burgon, Ferhaan Ahmad, Megan Sherwood, Dorothy Branco, Hiroko Wakimoto, Glenn I. Fishman, Vincent See, Colin L. Stewart, David A. Conner, Charles I. Berul, Christine E. Seidman, Jonathan G. Seidman   +15 more
semanticscholar   +4 more sources

The natural history of symptomatic cardiac conduction-system disease in end-stage renal disease [PDF]

Nephrology Dialysis Transplantation, 2016
Thomas R. Kambur, Mithilesh K. Das, Rajiv Agarwal   +2 more
semanticscholar   +4 more sources

Is there an association between Fahr′s disease and cardiac conduction system disease?: A case report

Journal of Research in Medical Sciences, 2012
Background: Fahr′s disease is a rare neurodegenerative disorder of unknown cause characterized by idiopathic basal ganglia calcification that is associated with neuropsychiatric and cognitive impairment.
Prashanth Panduranga, Kadhim Sulaiman
doaj   +5 more sources

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling [PDF]

Scientific Reports, 2017
Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system.
Robert S. Stephenson, Andrew Atkinson, Petros Kottas, Filip Perde, Fatemeh Jafarzadeh, Mike Bateman, Paul A. Iaizzo, Jichao Zhao, Henggui Zhang, Robert H. Anderson, Jonathan C. Jarvis, Halina Dobrzynski   +11 more
doaj   +2 more sources