Results 121 to 130 of about 568,260 (340)

Cardiac Urea Cycle Activation by Time‐Restricted Feeding Protects Against Pressure Overload‐Induced Heart Failure

open access: yesAdvanced Science
Heart failure is a leading cause of mortality worldwide, necessitating the development of novel therapeutic and lifestyle interventions. Recent studies highlight a potential role of time‐restricted feeding (TRF) in the prevention and treatment of cardiac
Yanzhen Tan   +11 more
doaj   +1 more source

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

open access: yesAdvanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li   +8 more
wiley   +1 more source

Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction–relaxation cycle in isolated cardiac myofibrils [PDF]

open access: bronze, 2005
Martina Krüger   +7 more
openalex   +1 more source

The Effects of Physical Activity on Stress-induced Cardiac Fibrosis [PDF]

open access: yes, 2017
Purpose: This study examined whether routine physical activity limits stress-induced tissue remodeling processes that lead to cardiac fibrosis. The study also explored whether the cardiac urocortin 2/corticotropin releasing factor receptor 2β pathway was
Coste, Sarah C., Kinney, Erin M.
core   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans   +11 more
wiley   +1 more source

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

open access: yesAdvanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan   +8 more
wiley   +1 more source

Variation of cardiac cycle during prolonged cycling exercise.

open access: yesThe Annals of physiological anthropology, 1989
The purpose of this study was to elucidate the changes in heart rate (HR), systolic and diastolic time intervals accompanying prolonged cycling exercise. Seven healthy male students (N group) and seven male collegiate long distance runners (LDR group) underwent 60-min bicycle ergometer exercise loaded at 30% and 50% HRmax.
openaire   +3 more sources

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