Results 151 to 160 of about 577,063 (338)

Disentangling sensorimotor and cognitive cardioafferent effects: A cardiac-cycle-time study on spatial stimulus-response compatibility [PDF]

, 2020
Mauro F. Larra, Johannes B. Finke, Edmund Wascher, Hartmut Schächinger   +3 more
openalex   +1 more source

Neuregulin-1 enhances cell-cycle activity, delays cardiac fibrosis, and improves cardiac performance in rat pups with right ventricular pressure load [PDF]

, 2021
Guido P. L. Bossers, Marie Günthel, Diederik E. van der Feen, Quint A. J. Hagdorn, Anne‐Marie C. Koop, Karel van Duijvenboden, Phil Barnett, Marinus A.J. Borgdorff, Vincent M. Christoffels, Herman H.W. Silljé, Rolf M.F. Berger, Beatrijs Bartelds   +11 more
openalex   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Instrumentation to study myofibril mechanics from static to artificial simulations of cardiac cycle [PDF]

, 2016
Petr G. Vikhorev, Michael A. Ferenczi, Steven B. Marston   +2 more
openalex   +1 more source

Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle [PDF]

, 2023
Kristina B. Kooiker, Saffie Mohran, Kyrah L. Turner, Weikang Ma, Galina Flint, Lin Qi, Chengqian Gao, Yahan Zheng, Timothy S. McMillen, Christian Mandrycky, Amy Martinson, Max Mahoney-Schaefer, Jeremy C. Freeman, Elijah Gabriela Costales Arenas, An-Yu Tu, Thomas C. Irving, Michael A. Geeves, Bertrand C.W. Tanner, Michael Regnier, Jennifer Davis, Farid Moussavi‐Harami   +20 more
openalex   +1 more source

Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype

Advanced Healthcare Materials, EarlyView.
Replicating tissue‐specific extracellular matrix is crucial for understanding its role in disease. This work demonstrates independent control over stiffness, composition and 3D collagen architecture using hybrid scaffolds: patterned collagen perfused with defined hydrogels.
Xinyuan Song, Samantha C. Mitchell, Abbie N. Smart, William Hardiman, Daniel V. Bax, Ceri E. Staley, Catherine Probert, Pamela Collier, Marian Meakin, Alison A. Ritchie, Tania Mendonca, Amanda J. Wright, Victoria James, Anna M. Grabowska, Catherine L. R. Merry, Serena M. Best, Ruth E. Cameron, Jennifer C. Ashworth   +17 more
wiley   +1 more source

Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity

npj Regenerative Medicine
Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity. Calcium is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is ...
Lynn A. C. Devilée, Abou bakr M. Salama, Jessica M. Miller, Janice D. Reid, Qinghui Ou, Nourhan M. Baraka, Kamal Abou Farraj, Madiha Jamal, Yibing Nong, Todd K. Rosengart, Douglas Andres, Jonathan Satin, Tamer M. A. Mohamed, James E. Hudson, Riham R. E. Abouleisa   +14 more
doaj   +1 more source

Kidney Cell Cycle Arrest and Cardiac Biomarkers and Acute Kidney Injury Following Angiography: The Prevention of Serious Adverse Events Following Angiography (PRESERVE) Study [PDF]

, 2022
Raghavan Murugan, Monique Boudreaux-Kelly, John A. Kellum, Paul M. Palevsky, Steven D. Weisbord   +4 more
openalex   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source