Results 61 to 70 of about 568,260 (340)

MyoLoop: Design, development and validation of a standalone bioreactor for pathophysiological electromechanical in vitro cardiac studies

Experimental Physiology
Mechanical load is one of the main determinants of cardiac structure and function. Mechanical load is studied in vitro using cardiac preparations together with loading protocols (e.g., auxotonic, isometric).
Fotios G. Pitoulis, Jacob J. Smith, Blanca Pamias‐Lopez, Pieter P. deTombe, Danika Hayman, Cesare M. Terracciano   +5 more
doaj   +1 more source

Epigenetic regulation of cardiac myocyte differentiation

Frontiers in Genetics, 2014
Cardiac myocytes proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation.
Kyohei eOyama, Danny eEl-Nachef, Yiqiang eZhang, Patima eSdek, William Robb Maclellan   +4 more
doaj   +1 more source

CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]

, 2014
Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
core   +2 more sources

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Visualizing the Cardiac Cycle: A Useful Tool to Promote Student Understanding

Journal of Microbiology & Biology Education, 2011
The cardiac cycle is an important concept presented in human anatomy and physiology courses. At Kingsborough Community College, all Allied Health majors taking Anatomy & Physiology must understand the cardiac cycle to grasp more advanced concepts ...
Ivan Shun Ho
doaj   +1 more source

Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes

Frontiers in Pharmacology, 2022
The bromodomain and extra-terminal domain proteins (BETs) family serve as epigenetic “readers”, which recognize the acetylated histones and recruit transcriptional regulator complexes to chromatin, eventually regulating gene transcription.
Zhirong Lin, Zhenzhen Li, Zhen Guo, Yanjun Cao, Jingyan Li, Peiqing Liu, Zhuoming Li   +6 more
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Accuracy of prediction of infarct-related arrhythmic circuits from image-based models reconstructed from low and high resolution MRI. [PDF]

, 2015
Identification of optimal ablation sites in hearts with infarct-related ventricular tachycardia (VT) remains difficult to achieve with the current catheter-based mapping techniques.
Arevalo, Hermenegild, Ashikaga, Hiroshi, Deng, Dongdong, Halperin, Henry, McVeigh, Elliot, Pashakhanloo, Farhad, Prakosa, Adityo, Trayanova, Natalia   +7 more
core   +2 more sources

Ultrasound compared to Computed Tomography in identifying thoracic aortic aneurysms in patients with Giant Cell Arteritis

Arthritis Care &Research, Accepted Article.
Objectives The objectives of this study were to evaluate the correlation and agreement between ultrasound and computed tomography (CT) in measuring ascending aorta diameter in patients with giant cell arteritis (GCA) and to investigate the development of new ascending aortic aneurysms in patients with newly diagnosed GCA. Methods To achieve the primary
Anne C Bull Haaversen, Lene K Brekke, Tanaz A Kermani, Øyvind Molberg, Andreas P Diamantopoulos   +4 more
wiley   +1 more source

The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model

, 2004
In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a
Cherry E. M., Diego J. M. D., Hervé Henry, Wouter-Jan Rappel   +3 more
core   +1 more source