Results 51 to 60 of about 576,151 (244)

Taking Context to Heart: Momentary Emotions, Menstrual Cycle, and Cardiac Autonomic Regulation [PDF]

, 2019
Background. Emotions have long been discussed in conjunction with the autonomic nervous system. Most research on heart-mood linkages does not consider sex differences or an evident underlying mechanism for sex differences- sex hormone levels.
Simon, Shauna
core  

Complex patterns of spontaneous initiations and terminations of reentrant circulation in a loop of cardiac tissue

, 2008
A two-component model is developed that consists of a discrete loop of cardiac cells that circulates action potentials together with a cardiac pacing mechanism.
Anastasiou-Nana, Banville, Bub, C.K. Cheng, C.M. Baumgarten, Cain, Cain, Cain, Cao, Chay, Chen, Cheng, Cherry, Chialvo, Chow, Courtemanche, Courtemanche, Courtemanche, Cytrynbaum, D.M. Chan, De Bakker, Derksen, Downar, Elaydi, Fox, Fox, Frame, Gilmour, Girouard, Glass, H. Sedaghat, Hall, Harris, Hwang, Ito, J.W. Cain, Jack, Jalife, Kalb, Keener, Kocic, Koller, Koller, Krebs, Kunysz, Lampert, Liebovitch, Lown, M.A. Wood, Manios, Mickens, Mines, Mitchell, Moe, Nagai, Nolasco, Otani, Plonsey, Qu, Quan, Sedaghat, Sedaghat, Stein, Stubna, Ten Tusscher, Vinet, Watanabe, Watanabe, Winkle, Wood, Wood, Wood   +71 more
core   +1 more source

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: A phase 1 dose-escalation study [PDF]

, 2018
BackgroundThis phase 1 dose-escalation trial studied MM-302, a novel HER2-targeted PEGylated antibody-liposomal doxorubicin conjugate, in HER2-positive locally advanced/metastatic breast cancer.MethodsPatients were enrolled in four cohorts: MM-302 ...
Adiwijaya, Bambang S, Campbell, Karen, Geretti, Elena, Hendriks, Bart S, Krop, Ian E, LoRusso, Patricia, Ma, Cynthia, Miller, Kathy D, Molnár, István, Moyo, Victor, Munster, Pamela, Reynolds, Joseph, Shields, Anthony F, Siegel, Barry A, Wickham, Thomas J   +14 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

MyoLoop: Design, development and validation of a standalone bioreactor for pathophysiological electromechanical in vitro cardiac studies

Experimental Physiology
Mechanical load is one of the main determinants of cardiac structure and function. Mechanical load is studied in vitro using cardiac preparations together with loading protocols (e.g., auxotonic, isometric).
Fotios G. Pitoulis, Jacob J. Smith, Blanca Pamias‐Lopez, Pieter P. deTombe, Danika Hayman, Cesare M. Terracciano   +5 more
doaj   +1 more source

Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy.

PLoS ONE, 2014
Cardiac hypertrophy appears to be a specialized form of cellular growth that involves the proliferation control and cell cycle regulation. NIMA (never in mitosis, gene A)-related kinase-6 (Nek6) is a cell cycle regulatory gene that could induce centriole
Zhouyan Bian, Haihan Liao, Yan Zhang, Qingqing Wu, Heng Zhou, Zheng Yang, Jinrong Fu, Teng Wang, Ling Yan, Difei Shen, Hongliang Li, Qizhu Tang   +11 more
doaj   +1 more source

Interactions between cardiac activity and conscious somatosensory perception

, 2019
Fluctuations in the heart's activity can modulate the access of external stimuli to consciousness. The link between perceptual awareness and cardiac signals has been investigated mainly in the visual and auditory domain. Here, we investigated whether the
Al, E., Forschack, N., Gaebler, M., Grund, M., Motyka, P., Villringer, A.   +5 more
core   +1 more source

RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells [PDF]

, 2019
Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC ...
Jin, Yue, Kim, Il-man, Shen, Yan, Su, Xuan, Tang, Yaoliang, Weintraub, Neal L.   +5 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source