Results 51 to 60 of about 1,793,619 (305)

Mitigating ibrutinib‐induced ventricular arrhythmia and cardiac dysfunction with metformin [PDF]

BackgroundIbrutinib is a first‐line drug that targets Bruton's tyrosine kinase for the treatment of B cell cancer. However, cardiotoxicity induced by ibrutinib is a major side effect that limits its clinical use.
Yuan, Meng, Liu, Tong, Zhang, Qingling, Zhou, Zandong, Liu, Xing, Tse, Gary, Zhang, Yue, Zhao, Zhiqiang, Gao, P., Li, Guangping, Liu, Daiqi, Yuan, Ming, Li, Pengsha, Bao, Qiankun   +13 more
core   +2 more sources

IL-12p40 deletion aggravates lipopolysaccharide-induced cardiac dysfunction in mice

Frontiers in Cardiovascular Medicine, 2022
BackgroundCardiac dysfunction is one of the most common complications of sepsis and is associated with the adverse outcomes and high mortality of sepsis patients. IL-12p40, the common subunit of IL-12 and IL-23, has been shown to be involved in a variety
Menglin Liu, Zhen Wang, Jishou Zhang, Di Ye, Menglong Wang, Yao Xu, Mengmeng Zhao, Yongqi Feng, Xiyi Lu, Heng Pan, Wei Pan, Cheng Wei, Dan Tian, Wenqiang Li, Jingjun Lyu, Jing Ye, Jun Wan   +16 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass [PDF]

, 2007
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery.
Windolf Joachim, Scholz Martin, Francischetti, Ieda, Kranert Tilmann, Bitu-Moreno José, Moritz Anton, Francischetti Ieda, Kranert, Tilmann, Windolf, Joachim, Lögters, Tim Tobias, Bitu-Moreno, José, Margraf, Stefan, Abdel-Rahman Ulf, Abdel-Rahman, Ulf, Aybek, Tayfun, Grünwald, Frank (Prof. Dr.), Lögters Tim, Margraf Stefan, Grünwald Frank, Scholz, Martin, Moritz, Anton, Aybek Tayfun   +21 more
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor. [PDF]

, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Maddock Helen, Hussain, Afthab, Gharanei Mayel, Maddock, H, Janneh, Omar, Omar Janneh, Maddock, Helen L., Helen Maddock, Hussain, A, Gharanei, M., Hussain Afthab, Afthab Hussain, Janneh, O, Mayel Gharanei, Janneh Omar, Gharanei, M   +15 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice

Molecular Therapy: Nucleic Acids, 2016
Sepsis-induced myocardial dysfunction represents a major cause of death in intensive care units. Dysregulated microRNAs (miR)-155 has been implicated in multiple cardiovascular diseases and miR-155 can be induced by lipopolysaccharide (LPS). However, the
Hui Wang, Yihua Bei, Peipei Huang, Qiulian Zhou, Jing Shi, Qi Sun, Jiuchang Zhong, Xinli Li, Xiangqing Kong, Junjie Xiao   +9 more
doaj   +1 more source