Results 51 to 60 of about 576,149 (314)

Fetal major cardiac defects and placental dysfunction at 11-13 weeks' gestation [PDF]

, 2018
Objectives: To investigate the relationship between fetal major cardiac defects and markers of placental perfusion and function. Methods: This was a prospective screening study in singleton pregnancies at 11-13 weeks’ gestation.
Nicolaides, K. H., Kasapoglu, D., Kasapoglu, T., Akolekar, R., Fantasia, I., Syngelaki, A.   +5 more
core   +1 more source

Role of Cardiac Imaging Modalities in the Evaluation of COVID-19-Related Cardiomyopathy

Diagnostics, 2022
Cardiac involvement has been described during the course of SARS-CoV-2 disease (COVID-19), with different manifestations. Several series have reported only increased cardiac troponin without ventricular dysfunction, others the acute development of left ...
Antonella Cecchetto, Stefano Nistri, Giulia Baroni, Gianpaolo Torreggiani, Patrizia Aruta, Valeria Pergola, Anna Baritussio, Marco Previtero, Chiara Palermo, Sabino Iliceto, Donato Mele   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass

, 2007
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery.
Windolf Joachim, Scholz Martin, Francischetti, Ieda, Kranert Tilmann, Bitu-Moreno José, Moritz Anton, Francischetti Ieda, Kranert, Tilmann, Windolf, Joachim, Lögters, Tim Tobias, Bitu-Moreno, José, Margraf, Stefan, Abdel-Rahman Ulf, Abdel-Rahman, Ulf, Aybek, Tayfun, Grünwald, Frank (Prof. Dr.), Lögters Tim, Margraf Stefan, Grünwald Frank, Scholz, Martin, Moritz, Anton, Aybek Tayfun   +21 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor. [PDF]

, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Maddock Helen, Hussain, Afthab, Gharanei Mayel, Maddock, H, Janneh, Omar, Omar Janneh, Maddock, Helen L., Helen Maddock, Hussain, A, Gharanei, M., Hussain Afthab, Afthab Hussain, Janneh, O, Mayel Gharanei, Janneh Omar, Gharanei, M   +15 more
core   +1 more source

Cardiac Mitochondria Dysfunction in Dyslipidemic Mice

International Journal of Molecular Sciences, 2022
Dyslipidemia triggers many severe pathologies, including atherosclerosis and chronic inflammation. Several lines of evidence, including our studies, have suggested direct effects of dyslipidemia on cardiac energy metabolism, but details of these effects are not clear.
Alicja Braczko, Barbara Kutryb-Zajac, Agata Jedrzejewska, Oliwia Krol, Paulina Mierzejewska, Magdalena Zabielska-Kaczorowska, Ewa M. Slominska, Ryszard T. Smolenski   +7 more
openaire   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Cardiac biomarkers for screening and prognostication of cardiac dysfunction in critically ill patients

ESC Heart Failure
Aims This study aimed to assess the use of high‐sensitivity troponin T (hsTNT) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) in screening for cardiac dysfunction [left ventricular (LV) systolic or diastolic dysfunction or right ventricular (RV)
Oscar Cavefors, Freyr Einarsson, Jakob Holmqvist, Odd Bech‐Hanssen, Sven‐Erik Ricksten, Björn Redfors, Jonatan Oras   +6 more
doaj   +1 more source

Cardiac dysfunction in patients with end-stage liver disease, prevalence, and impact on outcome: a comparative prospective cohort study

Egyptian Liver Journal, 2022
Background Without firm diagnostic criteria, the exact prevalence of cirrhotic cardiomyopathy still remains unknown. Its estimation is rather a difficult task as the disease is generally latent and shows itself only when the patient is subjected to overt
Hatem H. Al Atroush, Khaled H. Mohammed, Fatma M. Nasr, Mohammed I. Al Desouky, Mohammed A. Rabie   +4 more
doaj   +1 more source