Results 41 to 50 of about 57,859 (256)

Targeting necroptosis as therapeutic potential in chronic myocardial infarction

Journal of Biomedical Science, 2021
Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD mortality.
Chanon Piamsiri, Chayodom Maneechote, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon Chattipakorn   +4 more
doaj   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Cardiac Implantable Electronic Device (CIED) Infections, Associated Risk Factors and Optimization in Reducing CIED Infections; An Experience of Tertiary Care Hospital of Pakistan

Pakistan Armed Forces Medical Journal
Objective: To determine the frequency of infections in cardiac implantable Electronic device patients, identify risk factors, and look for optimization in reducing Cardiac Implantable Electronic Device infections, with a resultant decrease in mortality ...
Ghulam Kubra, Ghazala Irfan, Syed Ghazi Abbas, Kanwal Fatima Aamir, Mir Waqas Baloch, Abdul Mueed   +5 more
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Fusion Imaging of Non-Invasive and Invasive Cardiac Electroanatomic Mapping in Patients with Ventricular Ectopic Beats: A Feasibility Analysis in a Case Series

Diagnostics
In patients with premature ventricular contractions (PVCs), non-invasive mapping could locate the PVCs’ origin on a personalized 3-dimensional (3D) heart model and, thus, facilitate catheter ablation therapy planning. The aim of our report is to evaluate
Matilda Muça, Stepan Zubarev, Dirk Bastian, Janusch Walaschek, Veronica Buia, Harald Rittger, Arsenii Dokuchaev, Thomas Bayer, Laura Vitali-Serdoz   +8 more
doaj   +1 more source

From Sourcing to End‐of‐Life: Sustainability Challenges and Opportunities in Organic Bioelectronics

Advanced Science, EarlyView.
Organic bioelectronics bridges biology and electronics using organic mixed ionic/electronic conductors. This Perspective addresses sustainability across the full lifecycle of organic bioelectronic materials and devices, offering a framework to guide material sourcing, synthesis, fabrication, application, and end‐of‐life strategies toward bioelectronic ...
Gwennaël Dufil, Marine Batista, Andrea Bionda, Erica Zeglio   +3 more
wiley   +1 more source

Successful Right Sided Subcutaneous Implantable Cardioverter‐Defibrillator Implantation in Situs Inversus Dextrocardia: A Case Report and Literature Review

Clinical Case Reports
This case report details the successful implantation of a subcutaneous implantable cardioverter‐defibrillator (S‐ICD) in a 70‐year‐old male with situs inversus dextrocardia, a rare congenital condition where the heart and visceral organs are reversed ...
Bahareh Karimian, Majid Haghjoo, Akam Ramezani, Mehrdad Khajehei   +3 more
doaj   +1 more source

Analysis of Outcomes in 8304 Patients Undergoing Lead Extraction for Infection

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Patients undergoing lead extraction for infected devices have worse outcomes compared with those with noninfected devices. We assessed predictors of in‐hospital mortality and procedure‐related major adverse events (MAEs) in a large cohort ...
Ryan G. Aleong, Matthew M. Zipse, Christine Tompkins, Muhammad Aftab, Paul Varosy, William Sauer, David Kao   +6 more
doaj   +1 more source

Safety and efficacy of cardioneuroablation for vagal bradycardia in a single arm prospective study

Scientific Reports
Cardioneuroablation (CNA) is currently considered as a promising treatment option for patients with symptomatic bradycardia caused by vagotonia. This study aims to further investigate its safety and efficacy in patients suffering from vagal bradycardia ...
Yafan Han, Mingliang Shao, Hang Yang, Huaxin Sun, Wanyue Sang, Lu Wang, Liang Wang, Suxia Yang, Yi Jian, Baopeng Tang, Yaodong Li   +10 more
doaj   +1 more source

Clinical Anatomy of the Left and Right Atrial Appendages in Humans: Comparative and Developmental Perspective

Clinical Anatomy, EarlyView.
ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová, Caroline Neradilová, Jan Kovanda, Jan Burkert, Jiří Beneš Jr., Martin Bartos, Theodor Adla, Vojtech Melenovsky, Alena Kvasilova, Ondrej Fabian, Ondrej Naňka, David Sedmera   +11 more
wiley   +1 more source