Results 81 to 90 of about 766,970 (293)

High-performance cell-based simulations of cardiac electrophysiology using task parallelism

International audienceCardiac electrophysiology is the study of electrical activity in the heart; disorders of the heart’s electrical synchronisation system, named cardiac arrhythmias, are responsible for half of the deaths related to cardiovascular ...
Bettonte, Giorgio
core   +2 more sources

Clinical analysis of cardiac autonomic ganglion plexus ablation for bradyarrhythmia: Research protocol for an intervention study

Anatolian Journal of Cardiology, 2021
Mingliang Shao, YaoDong Li, Xianhui Zhou, Yanmei Lu, Ling Zhang, Baopeng Tang   +5 more
doaj   +1 more source

Clinical Anatomy of the Left and Right Atrial Appendages in Humans: Comparative and Developmental Perspective

Clinical Anatomy, EarlyView.
ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová, Caroline Neradilová, Jan Kovanda, Jan Burkert, Jiří Beneš Jr., Martin Bartos, Theodor Adla, Vojtech Melenovsky, Alena Kvasilova, Ondrej Fabian, Ondrej Naňka, David Sedmera   +11 more
wiley   +1 more source

Pharmacological inhibition of apoptosis, necroptosis, and ferroptosis confers effective cardioprotection in post-myocardial infarction in rats

Scientific Reports
Cardiovascular conditions account for millions of deaths globally. Myocardial infarction (MI) remains the foremost cause of cardiovascular death. Post-MI pathology can activate a diverse type of programmed cell death (PCD), which aggravates cardiac ...
Chanon Piamsiri, Chayodom Maneechote, Kewarin Jinawong, Busarin Arunsak, Titikorn Chunchai, Siriporn C. Chattipakorn, Nipon Chattipakorn   +6 more
doaj   +1 more source

Quo Vadis in Anatomical Research? Preserving the Conditions for Discovery in an Era of Predictable Outcomes

Clinical Anatomy, EarlyView.
ABSTRACT Contemporary anatomical research has become increasingly integrated with clinical practice, generating substantial benefits for patient care and strengthening the translational relevance of the discipline. At the same time, some of the most influential anatomical advances have emerged from investigations whose eventual significance could not ...
Joe Iwanaga, Shane Tubbs
wiley   +1 more source

Global trends and epidemiological impact of metabolic risk factors on atrial fibrillation and atrial flutter from 1990 to 2021

Scientific Reports
Atrial fibrillation (AF) and atrial flutter (AFL) are cardiac arrhythmias associated with high morbidity and mortality. This cross-sectional observational study assesses the epidemiological burden of AF/AFL concerning metabolic risk factors using the ...
Junqing Liang, Jun Shen, Yankai Guo, Manzeremu Rejiepu, Xiuwen Ling, Xiaoyan Wang, Yi Jian, Xing Zhang, Shijie Shao, Baopeng Tang, Ling Zhang   +10 more
doaj   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Clinical characteristics and outcome of cardiac resynchronization therapy for heart failure in National Hospital of Sri Lanka from year 2005 to 2020 – a retrospective observational study

BMC Cardiovascular Disorders
Background Cardiac resynchronization therapy (CRT) has been a well-established treatment modality for moderate to severe left ventricular systolic dysfunction with left ventricular desynchrony.
Sandun Prabath Iddagoda Hewage Don, Kuruppumullage Chamini Nuwansika Kuruppu, Asunga Dunuwille, Asanka Wijewardena, Rohan Gunawardena   +4 more
doaj   +1 more source

Effects of sodium–glucose co‐transporter inhibitors on individual clinical endpoints and quality of life

ESC Heart Failure, Volume 12, Issue 2, Page 1271-1282, April 2025.
Effects of SGLTi on Individual Clinical Endpoints and Quality‐of‐Life: outcome from randomized data. Abstract Aims Sodium–glucose co‐transporter inhibitors (SGLTis) have cardiovascular protective effects. We aimed to assess the effects of SGLTis on individual hard clinical endpoints and quality of life (QoL) in patients with cardiovascular risk factors.
Jia Liao, Yang Chen, Zhiyu Ling, Helmut Pürerfellner, Martin Martinek, Michael Derndorfer, Johannes Niel, Ramin Ebrahimi, Matthias Heukäufer, Sarah Janschel, Davide Di Vece, Klaus Empen, Astrid Hummel, Bishwas Chamling, Piotr Futyma, Fahim Ebrahimi, Márcio G. Kiuchi, Shaowen Liu, Yuehui Yin, Alexandra Schratter, Willem‐Jan Acou, Philipp Sommer, Boris Schmidt, Julian K. R. Chun, Christian Meyer, Marcus Dörr, Christian Templin, Shaojie Chen   +27 more
wiley   +1 more source