Results 101 to 110 of about 145,404 (307)

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Fibroblast Reprogramming in Cardiac Repair

JACC: Basic to Translational Science
Cardiovascular disease is one of the major causes of death worldwide. Limited proliferative capacity of adult mammalian cardiomyocytes has prompted researchers to exploit regenerative therapy after myocardial injury, such as myocardial infarction, to attenuate heart dysfunction caused by such injury.
Wang, Qiaozi, Spurlock, Brian, Liu, Jiandong, Qian, Li   +3 more
openaire   +2 more sources

Cardiac fibroblasts: from origin to injury [PDF]

Current Opinion in Physiology, 2018
The cardiac fibroblast has essential roles in production and maintenance of extracellular matrix. While its role in maladaptive myocardial remodeling has been a focus of many studies, the cardiac fibroblast has become a topic of great interest as a contributor to heart physiology and as a therapeutic target.
openaire   +2 more sources

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction

Journal of Advanced Research
Introduction: N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an m6A “eraser”, is responsible for decreased m6A modification.
Kun Yang, Yongchao Zhao, Jingjing Hu, Rifeng Gao, Jiaran Shi, Xiang Wei, Juntao Chen, Kai Hu, Aijun Sun, Junbo Ge   +9 more
doaj   +1 more source

MicroRNA-1-Mediated Inhibition of Cardiac Fibroblast Proliferation Through Targeting Cyclin D2 and CDK6

Frontiers in Cardiovascular Medicine, 2019
MicroRNA-1 (miRNA-1) has been long viewed as a muscle-specific miRNA and plays a critical role in myocardium and cardiomyocytes by controlling myocyte growth and rhythm. We identified that miRNA-1 is expressed in cardiac fibroblasts, which are one of the
Nedyalka Valkov, Nedyalka Valkov, Michelle E. King, Jacob Moeller, Hong Liu, Xiaofei Li, Peng Zhang   +6 more
doaj   +1 more source

Induction of Cardiomyocytes From Cardiac Fibroblasts [PDF]

Circulation: Cardiovascular Genetics, 2012
The laboratory of which the authors are part had previously reported that a combination of 3 genes encoding transcription factors ( Gata4 , Mef2c , and Tbx5 ) could reprogram various types of fibroblasts into cells that had cardiomyocyte-like properties in vitro and that could be successfully transplanted into mouse heart; the authors hypothesized that
openaire   +2 more sources

Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. [PDF]

, 2019
With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
Agrawal, Azakie, Baio, Becker, Bergmann, Burridge, Camberos, Connor, Drosatos, Fermini, Fritsch-Yelle, Garrett-Bakelman, Gauthier, Huebsch, Hughson, Jha, Kim, Kwon, Oikonomopoulos, Perhonen, Rogers, Sharma, Sharma, Sharma, Sides, Spotnitz, Sun, Thomason, Wnorowski, Wu, Yu   +30 more
core   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Current perspectives of the signaling pathways directing neural crest induction. [PDF]

, 2012
The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I, Stuhlmiller, Timothy J   +1 more
core   +2 more sources