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Mechanism of sodium butyrate, a metabolite of gut microbiota, regulating cardiac fibroblast transdifferentiation via the NLRP3/Caspase-1 pyroptosis pathway. [PDF]
J Cardiothorac SurgDong T, Huang D, Jin Z.
europepmc +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala +1 more
wiley +1 more source
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Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction
Nature Cardiovascular Research, 2022Heart failure (HF) is a leading cause of morbidity and mortality. Studies in animal models and patients with HF revealed a prominent role for CD4+ T cell immune responses in the pathogenesis of HF and highlighted an active crosstalk between cardiac fibroblasts and IFNγ producing CD4+ T cells that results in profibrotic myofibroblast transformation ...
Njabulo Ngwenyama +10 more
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Annual Review of Physiology, 2020
Cardiac fibrosis is a pathological condition that occurs after injury and during aging. Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying methods for curbing excess deposition of extracellular matrix is a better understanding of the cardiac fibroblast, the cell responsible for collagen production.
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Cardiac fibrosis is a pathological condition that occurs after injury and during aging. Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying methods for curbing excess deposition of extracellular matrix is a better understanding of the cardiac fibroblast, the cell responsible for collagen production.
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The heart of cardiac reprogramming: The cardiac fibroblasts
Journal of Molecular and Cellular Cardiology, 2022Cardiovascular disease is the leading cause of death worldwide, outpacing pulmonary disease, infectious disease, and all forms of cancer. Myocardial infarction (MI) dominates cardiovascular disease, contributing to four out of five cardiovascular related deaths.
Shea N, Ricketts, Li, Qian
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Intracellular Signaling of Cardiac Fibroblasts
Comprehensive Physiology, 2015ABSTRACTLong regarded as a mere accessory cell for the cardiomyocyte, the cardiac fibroblast is now recognized as a critical determinant of cardiac function in health and disease. A recent renaissance in fibroblast‐centered research has fostered a better understanding than ever before of the biology of fibroblasts and their contractile counterparts ...
Patricia L, Roche +3 more
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Basic Signaling in Cardiac Fibroblasts
Journal of Cellular Physiology, 2016Cardiac fibroblasts are commonly known as supporting cells of the cardiac network and exert many essential functions that are fundamental for normal cardiac growth as well as for cardiac remodeling process during pathological conditions. This review focuses on the roles of cardiac fibroblasts in the formation and regulation of the extracellular matrix ...
Stéphanie, Chacar +3 more
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Cardiac Fibroblast Physiology and Pathology
Comprehensive Physiology, 2015ABSTRACTCardiac function is mediated by interactions between the cellular constituents of the heart, as well as the extracellular matrix. The major cell types of the heart include cardiac fibroblasts, myocytes, endothelial cells, and vascular smooth muscle cells.
David, Dostal +2 more
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