Results 271 to 280 of about 145,404 (307)
Some of the next articles are maybe not open access.
Communication Signals Between Cardiac Fibroblasts and Cardiac Myocytes
Journal of Cardiovascular Pharmacology, 2011Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural support during ventricular wall thickening from embryogenesis until adulthood. Cardiac fibroblasts, however, may also serve as a source of mitogens, extracellular matrix proteins, cytokines, and growth factors that could affect the phenotype of the cardiac myocyte ...
Filomena G, Ottaviano, Karen O, Yee
openaire +2 more sources
Developmental Pathways of Cardiac Fibroblasts
Cold Spring Harbor Perspectives in Biology, 2019Cardiac fibroblasts and fibrosis contribute to the pathogenesis of heart failure, a prevalent cause of mortality. Therefore, a majority of the existing information regarding cardiac fibroblasts is focused on their function and behavior after heart injury.
openaire +2 more sources
Cardiac fibroblasts: contributory role in septic cardiac dysfunction
Journal of Surgical Research, 2015Cardiac dysfunction is a frequent and severe complication of septic shock and contributes to the high mortality of sepsis. Although several mechanisms have been suspected to be responsible for sepsis-associated cardiac dysfunction, the precise cause(s) remains unclear to date.We tested the hypothesis that cardiac fibroblasts may play a critical role as
Kengo Tomita +7 more
openaire +2 more sources
Embryonary Mouse Cardiac Fibroblast Isolation
2018Mouse cardiac fibroblasts have been widely used as an in vitro model for studying fundamental biological processes and mechanisms underlying cardiac pathologies, as well as identifying potential therapeutic targets. Cardiac FBs are relatively easy to culture in a dish and can be manipulated using molecular and pharmacological tools. Because FBs rapidly
Alejandra, Garate-Carrillo +1 more
openaire +2 more sources
Hormonal regulation of cardiac fibroblast function
European Heart Journal, 1995In arterial hypertension or congestive heart failure, myocardial fibrosis is associated with an activated renin-angiotensin-aldosterone system (RAAS). This reactive fibrosis presents as an excessive accumulation of fibrillar collagen within the normal connective tissue structures of the myocardium in either ventricle, irrespective of its haemodynamic ...
C G, Brilla +3 more
openaire +2 more sources
Unveiling Human Cardiac Fibroblast Membrane Proteome
PROTEOMICS, 2018Abstract Cardiac fibroblasts (CFs) are one of the main cell populations in the heart and play important roles in tissue homeostasis and myocardial fibrosis. The study of these cells has been hampered by the lack of reliable membrane markers: none of the antigens currently used for characterization and isolation of CFs is unique for ...
Maria João, Sebastião +4 more
openaire +2 more sources
Lnc-ing fibroblasts to cardiac fibrosis
Science, 2017Cardiac Fibrosis Therapies for cardiac injury typically focus on cardiomyocytes, the contractile cells of the heart. But cardiac fibroblasts can play a key role in the pathogenesis of heart failure by depositing extracellular matrix to compensate for reduced cardiac function. Micheletti et al.
openaire +2 more sources
GPCRomics of cardiac fibroblasts and cardiac fibrosis
The FASEB Journal, 2016G‐protein coupled receptors (GPCRs) are the largest category of cell surface receptors, serving as the most widely used set of targets for pharmacological intervention. Seeking to identify novel targets for cardiac fibrosis, we have used mRNA‐based (GPCRomic) methods to detect and quantify (i.e., profile) non ...
Krishna Sriram +3 more
openaire +1 more source
Scar fibroblasts affect cardiac excitability
Nature Cardiovascular Research, 2023openaire +2 more sources