Results 101 to 110 of about 928,242 (288)

Fibroblast Reprogramming in Cardiac Repair

JACC: Basic to Translational Science
Cardiovascular disease is one of the major causes of death worldwide. Limited proliferative capacity of adult mammalian cardiomyocytes has prompted researchers to exploit regenerative therapy after myocardial injury, such as myocardial infarction, to attenuate heart dysfunction caused by such injury.
Wang, Qiaozi, Spurlock, Brian, Liu, Jiandong, Qian, Li   +3 more
openaire   +2 more sources

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Cardiac fibroblasts: more than mechanical support.

, 2017
Fibroblasts are cells with a structural function, synthesizing components of the extracellular matrix. They are accordingly associated with various forms of connective tissue. During cardiac development fibroblasts originate from different sources.
Doppler, Stefanie A;Carvalho, Catarina;Lahm, Harald;Deutsch, Marcus-André;Dreßen, Martina;Puluca, Nazan;Lange, Rüdiger;Krane, Markus
core   +1 more source

Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression [PDF]

, 2015
Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma ...
Gersten, Adam, Prystowsky, Michael, Wang, Yanghua, Moleirinho, Susana, Gunn-Moore, Frank, Reynolds, Paul Andrew   +5 more
core   +1 more source

Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast Subpopulations

Cardiology Research and Practice
Background. Cardiomyopathy encompasses a broad spectrum of diseases affecting myocardial tissue, characterized clinically by abnormalities in cardiac structure, heart failure, and/or arrhythmias.
Wenyang Nie, Zhijie Zhao, Yuhang Liu, Youcao Wang, Jingwen Zhang, Ying Hu, Yang Liu, Yong Wang, Zhen Wang   +8 more
doaj   +1 more source

Macrophage Migration Inhibitory Factor (MIF) Expression Increases during Myocardial Infarction and Supports Pro-Inflammatory Signaling in Cardiac Fibroblasts

Biomolecules, 2019
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine known to play a major role in inflammatory diseases such as myocardial infarction (MI), where its expression increases.
Svenja Voss, Saskia Krüger, Katharina Scherschel, Svenja Warnke, Michael Schwarzl, Benedikt Schrage, Evaldas Girdauskas, Christian Meyer, Stefan Blankenberg, Dirk Westermann, Diana Lindner   +10 more
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Properties and Immune Function of Cardiac Fibroblasts.

, 2017
This chapter will discuss the role of cardiac fibroblasts as a target of various immunological inputs as well as an immunomodulatory hub of the heart through interaction with immune cell types and chemokine or cytokine signaling.
Furtado, Milena B, Muneer Hasham, Milena B. Furtado, Hasham, Muneer G   +3 more
core   +1 more source

Long QT syndrome type 3 gain-of-function of Nav1.5 increases ventricular fibroblasts proliferation and pro-fibrotic factors

Communications Biology
The long QT syndrome type 3 (LQT3) is a cardiac channelopathy caused by gain-of-function mutations in the SCN5A gene, encoding the sodium channel Nav1.5.
Claire Castro, Justine Patin, Cyrielle Jajkiewicz, Franck Chizelle, Cynthia Ore Cerpa, Agnès Tessier, Eva Le Pogam, Imen Fellah, Isabelle Baró, Flavien Charpentier, Mickaël Derangeon   +10 more
doaj   +1 more source

Primary, cardiac, fibroblastic osteosarcoma

Medicine, 2018
Primary cardiac osteosarcoma is a rare tumor. To our knowledge, only 15 cases have been reported in the literature in the past 10 years. We describe a case of primary, cardiac, fibroblastic osteosarcoma in a 42-year-old woman.A 42-year-old woman with a 10-day history of chest pain.
Li, Yangyang, Ye, Teng, Gu, Qianru, Dong, Lei, Chen, Guorong, Lu, Shanshan   +5 more
openaire   +2 more sources