Results 81 to 90 of about 928,242 (288)

Role of TKIs on activating cardiac fibroblasts

Lam, Chi KeungNon-specific anticancer drugs show a wide range of adverse effects, including irreversible cardiotoxicity. To limit such events, tyrosine kinase inhibitors (TKIs) are designed to specifically inhibit the receptor tyrosine kinases (RTKs ...
Chowdhury, Visnu Pritom
core   +1 more source

STAT1/3 and ERK1/2 Synergistically Regulate Cardiac Fibrosis Induced by High Glucose

Cellular Physiology and Biochemistry, 2013
Background: Hyperglycaemia promotes the proliferation of cardiac fibroblasts (CFs) and collagen synthesis in CFs. However, the molecular mechanism underlying the effects of HG on proliferation and collagen synthesis of CF, is not completely understood ...
Bin Dai, Meng Cui, Mei Zhu, Wen-Ling Su, Ming-Cai Qiu, Hong Zhang   +5 more
doaj   +1 more source

Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances

Frontiers in Physiology, 2020
Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged ...
Xing Fu, Qianglin Liu, Chaoyang Li, Yuxia Li, Leshan Wang   +4 more
doaj   +1 more source

The effects of age and the expression of SPARC on extracellular matrix production by cardiac fibroblasts in 3-D cultures. [PDF]

PLoS ONE, 2013
Fibrillar collagen is the primary component of the cardiac interstitial extracellular matrix. This extracellular matrix undergoes dramatic changes from birth to adulthood and then into advanced age. As evidence, fibrillar collagen content was compared in
Jessica Trombetta-eSilva, Erik P Eadie, Yuhua Zhang, Russell A Norris, Thomas K Borg, Amy D Bradshaw   +5 more
doaj   +1 more source

Reversible and irreversible differentiation of cardiac fibroblasts [PDF]

Cardiovascular Research, 2013
Differentiation of cardiac fibroblasts (Fbs) into myofibroblasts (MyoFbs) is responsible for connective tissue build-up in myocardial remodelling. We examined MyoFb differentiation and reversibility.Adult rat cardiac Fbs were cultured on a plastic substratum providing mechanical stress, with conditions to obtain different levels of Fb differentiation ...
Driesen, Ronald B., Nagaraju, Chandan K., Abi-Char, Joëlle, Coenen, Tamara, Lijnen, Paul J., Fagard, Robert H., Sipido, Karin R., Petrov, Victor V.   +7 more
openaire   +2 more sources

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag‐ATMP Translation

Advanced Healthcare Materials, EarlyView.
Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis, Dimitrios Lefas, Maya Guilliams, Jackie Van Grootenbril, Isaak Decoene, Dimitrios Sakellariou, Bart Smeets, Stefanos Mourdikoudis, Ioannis Papantoniou   +8 more
wiley   +1 more source

Transcriptional control of cardiac fibroblast plasticity [PDF]

Journal of Molecular and Cellular Cardiology, 2016
Cardiac fibroblasts help maintain the normal architecture of the healthy heart and are responsible for scar formation and the healing response to pathological insults. Various genetic, biomechanical, or humoral factors stimulate fibroblasts to become contractile smooth muscle-like cells called myofibroblasts that secrete large amounts of extracellular ...
Janet K, Lighthouse, Eric M, Small
openaire   +2 more sources

Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis

International Journal of Inflammation, 2011
Most cardiac diseases caused by inflammation are associated with fibrosis in the heart. Fibrosis is characterized by the accumulation of fibroblasts and excess deposition of extracellular matrix (ECM), which results in the distorted organ architecture ...
Yasuhiro Yoshimatsu, Tetsuro Watabe
doaj   +1 more source

IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling

Communications Biology, 2023
The source and roles of fibroblasts and T-cells during maladaptive remodeling and myocardial fibrosis in the setting of pulmonary arterial hypertension (PAH) have been long debated.
Jamila H. Siamwala, Francesco S. Pagano, Patrycja M. Dubielecka, Malina J. Ivey, Jose Pedro Guirao-Abad, Alexander Zhao, Sonja Chen, Haley Granston, Jae Yun Jeong, Sharon Rounds, Onur Kanisicak, Sakthivel Sadayappan, Richard J. Gilbert   +12 more
doaj   +1 more source