Results 71 to 80 of about 928,242 (288)

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. [PDF]

, 2006
04.11.13 KB. Ok to add published version to spiral, oa article.BACKGROUND: Organ transplantation is presently often the only available option to repair a damaged heart.
Peters, NS, MacLeod Kenneth T, Patel Pravina, Themis Michael, Coutelle, Charles, Ma, Yu-Ling, Tolmachov Oleg, Tolmachov, Oleg, Yu-Ling Ma, Coutelle Charles, Yvonne Kienast, MacLeod, K, Tolmachov, O, Peters, N, Hilmar Spohr, Peters Nicholas S, Ma, Y, Patel, Pravina, Spohr, Hilmar, Kienast Yvonne, Themis, Michael, Ullrich, N, Ullrich Nina D, Pravina Patel, Ma Yu-Ling, Charles Coutelle, Kienast, Y, MacLeod, Kenneth T, Peters, Nicholas S, Ullrich, ND, Coutelle, C, Spohr Hilmar, Ma, YL, Spohr, H, Oleg Tolmachov, Nina D Ullrich, Macleod, KT, Themis, M, Kenneth T MacLeod, Nicholas S Peters, Michael Themis, Kienast, Yvonne, Ullrich, Nina, Patel, P   +43 more
core   +2 more sources

Tanshinone IIA Inhibits High Glucose-Induced Collagen Synthesis via Nuclear Factor Erythroid 2-Related Factor 2 in Cardiac Fibroblasts

Cellular Physiology and Biochemistry, 2018
Background/Aims: Diabetes is associated with increased incidence of myocardial dysfunction, which is partly characterized by interstitial and perivascular fibrosis.
Yi-Ting  Tsai, Shih-Hurng Loh, Chung-Yi Lee, Shiao-Ping Lee, Yen-Lin Chen, Tzu-Hurng Cheng, Chien-Sung Tsai   +6 more
doaj   +1 more source

Integrins, Focal Adhesions, and Cardiac Fibroblasts [PDF]

Journal of Investigative Medicine, 2009
How the myocardium undergoes geometric, structural, and molecular alterations that result in an end phenotype as might be seen in patients with dilated cardiomyopathy or after myocardial infarction is still poorly understood. Structural modification of the left ventricle, which occurs during these pathological states, results from long-term changes in ...
Ana Maria, Manso, Seok-Min, Kang, Robert S, Ross   +2 more
openaire   +2 more sources

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Origin of Cardiac Fibroblasts and the Role of Periostin [PDF]

Circulation Research, 2009
Abstract: Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the ventricles.
Paige, Snider, Kara N, Standley, Jian, Wang, Mohamad, Azhar, Thomas, Doetschman, Simon J, Conway   +5 more
openaire   +2 more sources

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Characterization of multiple ion channels in cultured human cardiac fibroblasts. [PDF]

PLoS ONE, 2009
BACKGROUND: Although fibroblast-to-myocyte electrical coupling is experimentally suggested, electrophysiology of cardiac fibroblasts is not as well established as contractile cardiac myocytes.
Gui-Rong Li, Hai-Ying Sun, Jing-Bo Chen, Yuan Zhou, Hung-Fat Tse, Chu-Pak Lau   +5 more
doaj   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source