Results 231 to 240 of about 928,242 (288)

PFKM-Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation. [PDF]

Adv Sci (Weinh)
Fang N, Zhang N, Jiang X, Yan S, Wang Z, Gao Q, Xu M, Mu L, Li X, Chen J, Zhang S, Duan Y, Yun F, Li L, Zhang Y, Gong Y.   +15 more
europepmc   +1 more source

Highly conductive and robust epidermal dry electrode for long‐term interval biopotential monitoring

FlexMat, EarlyView.
A freestanding PVA‐PBFDO conductive dry electrode combines high conductivity, flexibility, and environmental stability to enable long‐term, high‐fidelity electrophysiological (EP) signal monitoring. Its patterning capability further facilitates the fabrication of wearable and multi‐channel bioelectronic devices.
Anni Sun, Tenglong Luo, Huanxin Su, Zhengyan He, Fuchun Nan, Shuo Wang, Yu Wang, Yuanhao Wu, Lingyun Wang, Jie Zhang, William W. Yu   +10 more
wiley   +1 more source

A secretome atlas of cardiac fibroblasts from healthy and infarcted mouse hearts. [PDF]

Commun Biol
Bahr J, Poschmann G, Jungmann A, Busch M, Ding Z, Vogt J, Zalfen R, Steinhausen J, Euan Martínez AA, Wachtmeister T, Rickert D, Lautwein T, Alter C, Amrute JM, Lavine KJ, Köhrer K, Levkau B, Most P, Stühler K, Hesse J, Schrader J.   +20 more
europepmc   +1 more source

Activated cardiac fibroblasts are a primary source of high-molecular-weight hyaluronan production. [PDF]

Am J Physiol Cell Physiol
Little DT, Howard CM, Pendergraft E, Brittian KR, Audam TN, Lukudu EW, Smith J, Nguyen D, Nishida Y, Yamaguchi Y, Brainard RE, Singhal RA, Jones SP.   +12 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Cirrhosis Promotes Cardiac Fibrosis Development by Inhibiting Notch1 in Cardiac Fibroblasts. [PDF]

JACC Basic Transl Sci
Sun H, Song K, Zhou ZY, Tu B, Zhou Y, Lin LC, Liu ZY, Liu ZY, Sha JM, Shi Y, Yang JJ, Lu D, Zhao JY, Tao H.   +13 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway. [PDF]

Elife
Deng Y, He Y, Xu J, He H, Zhang M, Li G.
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source