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Senescent cardiac fibroblasts: A key role in cardiac fibrosis
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2023Cardiac fibroblasts are a cell population that controls the homeostasis of the extracellular matrix and orchestrates a damage response to maintain cardiac architecture and performance. Due to these functions, fibroblasts play a central role in cardiac fibrosis development, and there are large differences in matrix protein secretion profiles between ...
Guillermo Díaz-Araya
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The heart of cardiac reprogramming: The cardiac fibroblasts
Journal of Molecular and Cellular Cardiology, 2022Cardiovascular disease is the leading cause of death worldwide, outpacing pulmonary disease, infectious disease, and all forms of cancer. Myocardial infarction (MI) dominates cardiovascular disease, contributing to four out of five cardiovascular related deaths.
Shea N, Ricketts, Li, Qian
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Annual Review of Physiology, 2020
Cardiac fibrosis is a pathological condition that occurs after injury and during aging. Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying methods for curbing excess deposition of extracellular matrix is a better understanding of the cardiac fibroblast, the cell responsible for collagen production.
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Cardiac fibrosis is a pathological condition that occurs after injury and during aging. Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying methods for curbing excess deposition of extracellular matrix is a better understanding of the cardiac fibroblast, the cell responsible for collagen production.
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Cardiac Fibroblast Physiology and Pathology
Comprehensive Physiology, 2015ABSTRACT Cardiac function is mediated by interactions between the cellular constituents of the heart, as well as the extracellular matrix. The major cell types of the heart include cardiac fibroblasts, myocytes, endothelial cells, and vascular smooth muscle cells.
David, Dostal +2 more
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Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction
Nature Cardiovascular Research, 2022Heart failure (HF) is a leading cause of morbidity and mortality. Studies in animal models and patients with HF revealed a prominent role for CD4+ T cell immune responses in the pathogenesis of HF and highlighted an active crosstalk between cardiac fibroblasts and IFNγ producing CD4+ T cells that results in profibrotic myofibroblast transformation ...
Njabulo Ngwenyama +10 more
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Intracellular Signaling of Cardiac Fibroblasts
Comprehensive Physiology, 2015ABSTRACT Long regarded as a mere accessory cell for the cardiomyocyte, the cardiac fibroblast is now recognized as a critical determinant of cardiac function in health and disease. A recent renaissance in fibroblast‐centered research has fostered a better understanding than ever before of the biology of ...
Patricia L, Roche +3 more
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Developmental Pathways of Cardiac Fibroblasts
Cold Spring Harbor Perspectives in Biology, 2019Cardiac fibroblasts and fibrosis contribute to the pathogenesis of heart failure, a prevalent cause of mortality. Therefore, a majority of the existing information regarding cardiac fibroblasts is focused on their function and behavior after heart injury.
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GPCRomics of cardiac fibroblasts and cardiac fibrosis
The FASEB Journal, 2016G‐protein coupled receptors (GPCRs) are the largest category of cell surface receptors, serving as the most widely used set of targets for pharmacological intervention. Seeking to identify novel targets for cardiac fibrosis, we have used mRNA‐based (GPCRomic) methods to detect and quantify (i.e., profile) non ...
Krishna Sriram +3 more
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Communication Signals Between Cardiac Fibroblasts and Cardiac Myocytes
Journal of Cardiovascular Pharmacology, 2011Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural support during ventricular wall thickening from embryogenesis until adulthood. Cardiac fibroblasts, however, may also serve as a source of mitogens, extracellular matrix proteins, cytokines, and growth factors that could affect the phenotype of the cardiac myocyte ...
Filomena G, Ottaviano, Karen O, Yee
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Cardiac fibroblasts: contributory role in septic cardiac dysfunction
Journal of Surgical Research, 2015Cardiac dysfunction is a frequent and severe complication of septic shock and contributes to the high mortality of sepsis. Although several mechanisms have been suspected to be responsible for sepsis-associated cardiac dysfunction, the precise cause(s) remains unclear to date.We tested the hypothesis that cardiac fibroblasts may play a critical role as
Kengo Tomita +7 more
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