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Cardiac Fibrosis: The Beneficial Effects of Exercise in Cardiac Fibrosis
2017Numerous scientific findings have concluded that individuals who are active tend to develop less cardiovascular disease than those who enjoy more sedentary lifestyles. Animal models have further demonstrated that the beneficial effects of training on the heart effects of training are related to the signaling pathways of myocardial hypertrophy and ...
Jan, Kyselovič, John J, Leddy
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Cardiac MRI and Fibrosis Quantification
Cardiac Electrophysiology Clinics, 2019Left atrial fibrosis plays an important role in the pathophysiology of atrial fibrillation. Left atrial ablation is an effective and increasingly used strategy to restore and maintain sinus rhythm in patients with atrial fibrillation. Late gadolinium enhancement (LGE) MRI and custom image analysis software have been used to visualize and quantify ...
Eugene G, Kholmovski +2 more
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Epigenetic regulation of cardiac fibrosis
Cellular Signalling, 2013Cardiac fibrosis is characterized by excessive extracellular matrix accumulation that ultimately destroys tissue architecture and eventually abolishes normal function. In recent years, despite the underlying mechanisms of cardiac fibrosis are still unknown, numerous studies suggest that epigenetic modifications impact on the development of cardiac ...
Hui, Tao +5 more
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Radiation-induced cardiac fibrosis
The American Journal of Medicine, 1963Abstract Three cases of cardiac fibrosis are presented in which radiation is suggested as the cause. In one, death occurred as a result of fibrosis involving the conducting system twenty-three years after radiation; in another, rupture of the apex of the heart occurred fourteen months after radiotherapy. It is suggested that the diagnosis of radiation-
E, RUBIN +3 more
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Induction of Cardiac Fibrosis by Aldosterone
Journal of Molecular and Cellular Cardiology, 2000An intracardiac aldosterone system which responds to short- and long-term physiological stimuli has been described. This cardiac generated aldosterone has possibly autocrine or paracrine actions. Normal cardiac tissue contains mineralocorticoid receptors (MR) and cardiac high affinity MR are localized in cardiac myocytes and endothelial cells.
P, Lijnen, V, Petrov
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Adrenal steroids and cardiac fibrosis
Steroids, 1995Uninephrectomized rats maintained on 0.9% NaCl as drinking fluid and infused for 8 weeks with aldosterone 0.75 micrograms/h via subcutaneous osmotic minipumps respond with hypertension, cardiac hypertrophy, and both interstitial and perivascular cardiac fibrosis.
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GPCRomics of cardiac fibroblasts and cardiac fibrosis
The FASEB Journal, 2016G‐protein coupled receptors (GPCRs) are the largest category of cell surface receptors, serving as the most widely used set of targets for pharmacological intervention. Seeking to identify novel targets for cardiac fibrosis, we have used mRNA‐based (GPCRomic) methods to detect and quantify (i.e., profile) non ...
Krishna Sriram +3 more
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Animal Models of Cardiac Fibrosis
2005A collagen network, composed largely of type I and III fibrillar collagens, is found in the heart's interstitial space. This network has multiple functions, including the preservation of tissue architecture and chamber geometry. Given its tensile strength, type I collagen is a major determinant of tissue stiffness.
Yao, Sun, Karl T, Weber
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Nihon rinsho. Japanese journal of clinical medicine, 2007
S.J. Enna, David B. Bylund
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S.J. Enna, David B. Bylund
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Drug Discovery Today: Disease Models, 2006
Cardiac fibrosis is a common pathologic finding in several cardiac myopathic diseases. Clinical implications of the presence of fibrosis are still under intense investigation. Several mouse and rat models have been used to gain a better understanding of the mechanisms underlying disease development, which may have a potential role for the reversal of ...
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Cardiac fibrosis is a common pathologic finding in several cardiac myopathic diseases. Clinical implications of the presence of fibrosis are still under intense investigation. Several mouse and rat models have been used to gain a better understanding of the mechanisms underlying disease development, which may have a potential role for the reversal of ...
openaire +1 more source