Results 221 to 230 of about 215,781 (262)
Cardiomyocyte-derived BDNF restricts cardiac fibrosis by decreasing the activity of the TGF-β/Smad2/3 pathway and increasing Smad7 expression. [PDF]
Zhu Y +18 more
europepmc +1 more source
Septin4 Regulates Cardiac Fibrosis After Pressure Overload. [PDF]
Yücel D +9 more
europepmc +1 more source
Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis. [PDF]
Wang Z +17 more
europepmc +1 more source
Engineered T cell therapy for the treatment of cardiac fibrosis during chronic phase of myocarditis. [PDF]
Hua X +16 more
europepmc +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai +4 more
wiley +1 more source
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Journal of Molecular and Cellular Cardiology, 2022
Cells sense mechanical stress and changes in their matrix environment through the integrins, a family of heterodimeric surface receptors that bind to extracellular matrix ligands and trigger cytoskeletal remodeling, while transducing a wide range of intracellular signals.
Ruoshui, Li, Nikolaos G, Frangogiannis
openaire +4 more sources
Cells sense mechanical stress and changes in their matrix environment through the integrins, a family of heterodimeric surface receptors that bind to extracellular matrix ligands and trigger cytoskeletal remodeling, while transducing a wide range of intracellular signals.
Ruoshui, Li, Nikolaos G, Frangogiannis
openaire +4 more sources
Fibrosis and Cardiac Arrhythmias
Journal of Cardiovascular Pharmacology, 2011In this review article about fibrosis and arrhythmias, we show that the amount of collagen, a normal element of the heart muscle, increases with age and in heart disease. The relation between fibrosis and electrophysiological parameters such as conduction, fractionation of electrograms, abnormal impulse initiation as well as arrhythmogenicity is ...
Sanne, de Jong +3 more
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The role of periostin in cardiac fibrosis
Heart Failure Reviews, 2023Cardiac fibrosis, which is the buildup of proteins in the connective tissues of the heart, can lead to end-stage extracellular matrix (ECM) remodeling and ultimately heart failure. Cardiac remodeling involves changes in gene expression in cardiac cells and ECM, which significantly leads to the morbidity and mortality in heart failure.
Bao Qiao +3 more
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Cardiac Fibrosis and Arrhythmogenesis
Comprehensive Physiology, 2017ABSTRACT Myocardial injury, mechanical stress, neurohormonal activation, inflammation, and/or aging all lead to cardiac remodeling, which is responsible for cardiac dysfunction and arrhythmogenesis. Of the key histological components of cardiac remodeling, fibrosis either in the form of interstitial, patchy, or ...
Nguyen, M, Kiriazis, H, Gao, X, Du, X
openaire +3 more sources

