Results 151 to 160 of about 93,083 (312)

The efficacy and physiological bases of small muscle mass exercise in health and disease

open access: yesExperimental Physiology, EarlyView.
Abstract The conventional approach to aerobic exercise prescription involves large muscle mass exercise and the manipulation of variables such as training intensity, duration and frequency to promote desired adaptations. However, during whole‐body exercise, central limitations (i.e., neural, pulmonary and/or cardiac) constrain exercise tolerance and ...
Callum G. Brownstein
wiley   +1 more source

Electron dense and electron translucent transitional cardiac myocytes interactions.

open access: yes, 2013
(A), example of end-to-end interaction between EDTCM and electron translucent cardiac myocytes (ETTCM) forming a continuum at the spongy-compact interface.
Norman Hu (17778)   +5 more
core   +1 more source

Cerebrovascular regulation during heat stress

open access: yesExperimental Physiology, EarlyView.
Abstract Given that the brain is a highly metabolic organ and is enclosed by the skull, effective regulation of cerebral blood flow (CBF), not only for oxygen and nutrients supply but also as a means of convective heat exchange, is critical for preventing excessive elevations in brain temperature.
Kanoko Ito, Manabu Shibasaki
wiley   +1 more source

The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation

open access: yes, 2005
Background— The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated IK,ACh contributes to enhanced basal ...
Ravens, U.   +7 more
core  

Determination of L-Type Calcium Current in the Primary Hypertrophied Left Ventricular Cardiomyocytes of Hypertrophy Heart Rats/HHR [PDF]

open access: yes, 2009
Background: The molecular mechanisms responsible for electromechanical derangements found in primary left ventricular (LV) hypertrophy have not been clearly elucidated.
Danes, V. R. (Vennetia)   +1 more
core  

Small muscle mass aerobic exercise in health and disease: Unique insights into muscle vascular and metabolic control and performance

open access: yesExperimental Physiology, EarlyView.
Abstract Studies of small muscle mass exercise (SMME) have revealed that the peripheral O2 transport–utilization cascade is a dynamically regulated system in which perfusive and diffusive components can be selectively amplified, redistributed and mechanically limited depending on contraction pattern, recruitment strategy and intramuscular pressure ...
Shunsaku Koga   +4 more
wiley   +1 more source

The effect of glucose on cardiac AMP-activated protein kinase

open access: yes, 2009
AMP-activated protein kinase (AMPK) serves as an energy-sensing protein that is activated by a variety of metabolic stresses. Recent studies suggest that AMPK is also regulated by hormones and by nutrients such as glucose and fatty acids.
Tabidi, I.
core  

Mitochondrial peptide MOTS‐c suppresses systemic and cardiac inflammasome activation in a diabetic rat model

open access: yesExperimental Physiology, EarlyView.
Abstract Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy. The mitochondrial‐derived peptide mitochondrial open reading frame of the 12S rRNA type‐C (MOTS‐c) has emerged as a promising regulator of metabolic and inflammatory pathways.
Aimee R. Mills   +3 more
wiley   +1 more source

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